Shi, Jiajun, Zhang, Yanfeng ORCID: 0000-0002-3859-3839, Zheng, Wei ORCID: 0000-0003-1226-070X, Michailidou, Kyriaki ORCID: 0000-0001-7065-1237, Ghoussaini, Maya, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Lush, Michael, Milne, Roger L., Shu, Xiao-Ou, Beesley, Jonathan ORCID: 0000-0003-1942-325X, Kar, Siddhartha, Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker ORCID: 0000-0001-9320-8684, Beckmann, Matthias W., Zhao, Zhiguo, Guo, Xingyi, Benitez, Javier, Beeghly-Fadiel, Alicia, Blot, William, Bogdanova, Natalia V., Bojesen, Stig E., Brauch, Hiltrud ORCID: 0000-0001-7531-2736, Brenner, Hermann ORCID: 0000-0002-6129-1572, Brinton, Louise, Broeks, Annegien, Bruening, Thomas, Burwinkel, Barbara, Cai, Hui, Canisius, Sander, Chang-Claude, Jenny, Choi, Ji-Yeob, Couch, Fergus J., Cox, Angela, Cross, Simon S., Czene, Kamila, Darabi, Hatef, Devilee, Peter ORCID: 0000-0002-8023-2009, Droit, Arnaud, Dork, Thilo ORCID: 0000-0002-9458-0282, Fasching, Peter A., Fletcher, Olivia ORCID: 0000-0001-9387-7116, Flyger, Henrik, Fostira, Florentia, Gaborieau, Valerie, Garcia-Closas, Montserrat, Giles, Graham G., Grip, Mervi, Guenel, Pascal ORCID: 0000-0002-8359-518X, Haiman, Christopher A., Hamann, Ute, Hartman, Mikael ORCID: 0000-0001-5726-9965, Miao, Hui, Hollestelle, Antoinette, Hopper, John L., Hsiung, Chia-Ni, Investigators, KConFab, Ito, Hidemi, Jakubowska, Anna ORCID: 0000-0002-5650-0501, Johnson, Nichola, Torres, Diana, Kabisch, Maria, Kang, Daehee, Khan, Sofia ORCID: 0000-0003-4185-8882, Knight, Julia A., Kosma, Veli-Matti, Lambrechts, Diether ORCID: 0000-0002-3429-302X, Li, Jingmei ORCID: 0000-0001-8587-7511, Lindblom, Annika, Lophatananon, Artitaya, Lubinski, Jan ORCID: 0000-0003-2931-3003, Mannermaa, Arto, Manoukian, Siranoush, Le Marchand, Loic, Margolin, Sara, Marme, Frederik, Matsuo, Keitaro ORCID: 0000-0003-1761-6314, McLean, Catriona, Meindl, Alfons, Muir, Kenneth, Neuhausen, Susan L., Nevanlinna, Heli, Nord, Silje ORCID: 0000-0002-3271-5356, Borresen-Dale, Anne-Lise, Olson, Janet E., Orr, Nick, van den Ouweland, Ans M. W., Peterlongo, Paolo ORCID: 0000-0001-6951-6855, Putti, Thomas Choudary, Rudolph, Anja, Sangrajrang, Suleeporn, Sawyer, Elinor J., Schmidt, Marjanka K., Schmutzler, Rita K., Shen, Chen-Yang, Hou, Ming-Feng ORCID: 0000-0001-6030-9702, Shrubsole, Matha J., Southey, Melissa C., Swerdlow, Anthony ORCID: 0000-0001-5550-4159, Teo, Soo Hwang, Thienpont, Bernard ORCID: 0000-0002-8772-6845, Toland, Amanda E., Tollenaar, Robert A. E. M., Tomlinson, Ian, Truong, Therese, Tseng, Chiu-Chen, Wen, Wanqing, Winqvist, Robert, Wu, Anna H., Yip, Cheng Har, Zamora, Pilar M., Zheng, Ying, Floris, Giuseppe, Cheng, Ching-Yu ORCID: 0000-0003-0655-885X, Hooning, Maartje J., Martens, John W. M., Seynaeve, Caroline, Kristensen, Vessela N., Hall, Per, Pharoah, Paul D. P., Simard, Jacques, Chenevix-Trench, Georgia ORCID: 0000-0002-1878-2587, Dunning, Alison M., Antoniou, Antonis C., Easton, Douglas F., Cai, Qiuyin and Long, Jirong ORCID: 0000-0002-7433-9766
(2016).
Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer.
Int. J. Cancer, 139 (6).
S. 1303 - 1318.
HOBOKEN:
WILEY.
ISSN 1097-0215
Full text not available from this repository.
Abstract
Previous genome-wide association studies among women of European ancestry identified two independent breast cancer susceptibility loci represented by single nucleotide polymorphisms (SNPs) rs13281615 and rs11780156 at 8q24. A fine-mapping study across 2.06 Mb (chr8: 127,561,724-129,624,067, hg19) in 55,540 breast cancer cases and 51,168 controls within the Breast Cancer Association Consortium was conducted. Three additional independent association signals in women of European ancestry, represented by rs35961416 (OR=0.95, 95% CI=0.93-0.97, conditional p=5.8 x 10(-6)), rs7815245 (OR=0.94, 95% CI=0.91-0.96, conditional p=1.1 x 10(-6)) and rs2033101 (OR=1.05, 95% CI=1.02-1.07, conditional p=1.1 x 10(-4)) were found. Integrative analysis using functional genomic data from the Roadmap Epigenomics, the Encyclopedia of DNA Elements project, the Cancer Genome Atlas and other public resources implied that SNPs rs7815245 in Signal 3, and rs1121948 in Signal 5 (in linkage disequilibrium with rs11780156, r(2) = 0.77), were putatively functional variants for two of the five independent association signals. The results highlighted multiple 8q24 variants associated with breast cancer susceptibility in women of European ancestry.
Item Type: |
Journal Article
|
Creators: |
Creators | Email | ORCID | ORCID Put Code |
---|
Shi, Jiajun | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zhang, Yanfeng | UNSPECIFIED | orcid.org/0000-0002-3859-3839 | UNSPECIFIED | Zheng, Wei | UNSPECIFIED | orcid.org/0000-0003-1226-070X | UNSPECIFIED | Michailidou, Kyriaki | UNSPECIFIED | orcid.org/0000-0001-7065-1237 | UNSPECIFIED | Ghoussaini, Maya | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bolla, Manjeet K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wang, Qin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dennis, Joe | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lush, Michael | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Milne, Roger L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Shu, Xiao-Ou | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Beesley, Jonathan | UNSPECIFIED | orcid.org/0000-0003-1942-325X | UNSPECIFIED | Kar, Siddhartha | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Andrulis, Irene L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Anton-Culver, Hoda | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Arndt, Volker | UNSPECIFIED | orcid.org/0000-0001-9320-8684 | UNSPECIFIED | Beckmann, Matthias W. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zhao, Zhiguo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Guo, Xingyi | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Benitez, Javier | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Beeghly-Fadiel, Alicia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Blot, William | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bogdanova, Natalia V. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bojesen, Stig E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Brauch, Hiltrud | UNSPECIFIED | orcid.org/0000-0001-7531-2736 | UNSPECIFIED | Brenner, Hermann | UNSPECIFIED | orcid.org/0000-0002-6129-1572 | UNSPECIFIED | Brinton, Louise | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Broeks, Annegien | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bruening, Thomas | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Burwinkel, Barbara | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cai, Hui | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Canisius, Sander | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chang-Claude, Jenny | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Choi, Ji-Yeob | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Couch, Fergus J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cox, Angela | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cross, Simon S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Czene, Kamila | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Darabi, Hatef | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Devilee, Peter | UNSPECIFIED | orcid.org/0000-0002-8023-2009 | UNSPECIFIED | Droit, Arnaud | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dork, Thilo | UNSPECIFIED | orcid.org/0000-0002-9458-0282 | UNSPECIFIED | Fasching, Peter A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fletcher, Olivia | UNSPECIFIED | orcid.org/0000-0001-9387-7116 | UNSPECIFIED | Flyger, Henrik | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fostira, Florentia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gaborieau, Valerie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Garcia-Closas, Montserrat | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Giles, Graham G. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Grip, Mervi | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Guenel, Pascal | UNSPECIFIED | orcid.org/0000-0002-8359-518X | UNSPECIFIED | Haiman, Christopher A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hamann, Ute | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hartman, Mikael | UNSPECIFIED | orcid.org/0000-0001-5726-9965 | UNSPECIFIED | Miao, Hui | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hollestelle, Antoinette | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hopper, John L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hsiung, Chia-Ni | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Investigators, KConFab | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ito, Hidemi | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Jakubowska, Anna | UNSPECIFIED | orcid.org/0000-0002-5650-0501 | UNSPECIFIED | Johnson, Nichola | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Torres, Diana | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kabisch, Maria | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kang, Daehee | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Khan, Sofia | UNSPECIFIED | orcid.org/0000-0003-4185-8882 | UNSPECIFIED | Knight, Julia A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kosma, Veli-Matti | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lambrechts, Diether | UNSPECIFIED | orcid.org/0000-0002-3429-302X | UNSPECIFIED | Li, Jingmei | UNSPECIFIED | orcid.org/0000-0001-8587-7511 | UNSPECIFIED | Lindblom, Annika | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lophatananon, Artitaya | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lubinski, Jan | UNSPECIFIED | orcid.org/0000-0003-2931-3003 | UNSPECIFIED | Mannermaa, Arto | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Manoukian, Siranoush | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Le Marchand, Loic | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Margolin, Sara | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Marme, Frederik | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Matsuo, Keitaro | UNSPECIFIED | orcid.org/0000-0003-1761-6314 | UNSPECIFIED | McLean, Catriona | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Meindl, Alfons | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Muir, Kenneth | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Neuhausen, Susan L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nevanlinna, Heli | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nord, Silje | UNSPECIFIED | orcid.org/0000-0002-3271-5356 | UNSPECIFIED | Borresen-Dale, Anne-Lise | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Olson, Janet E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Orr, Nick | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | van den Ouweland, Ans M. W. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Peterlongo, Paolo | UNSPECIFIED | orcid.org/0000-0001-6951-6855 | UNSPECIFIED | Putti, Thomas Choudary | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rudolph, Anja | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sangrajrang, Suleeporn | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sawyer, Elinor J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schmidt, Marjanka K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schmutzler, Rita K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Shen, Chen-Yang | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hou, Ming-Feng | UNSPECIFIED | orcid.org/0000-0001-6030-9702 | UNSPECIFIED | Shrubsole, Matha J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Southey, Melissa C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Swerdlow, Anthony | UNSPECIFIED | orcid.org/0000-0001-5550-4159 | UNSPECIFIED | Teo, Soo Hwang | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Thienpont, Bernard | UNSPECIFIED | orcid.org/0000-0002-8772-6845 | UNSPECIFIED | Toland, Amanda E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tollenaar, Robert A. E. M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tomlinson, Ian | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Truong, Therese | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tseng, Chiu-Chen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wen, Wanqing | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Winqvist, Robert | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wu, Anna H. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Yip, Cheng Har | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zamora, Pilar M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zheng, Ying | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Floris, Giuseppe | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cheng, Ching-Yu | UNSPECIFIED | orcid.org/0000-0003-0655-885X | UNSPECIFIED | Hooning, Maartje J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Martens, John W. M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Seynaeve, Caroline | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kristensen, Vessela N. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hall, Per | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Pharoah, Paul D. P. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Simard, Jacques | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chenevix-Trench, Georgia | UNSPECIFIED | orcid.org/0000-0002-1878-2587 | UNSPECIFIED | Dunning, Alison M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Antoniou, Antonis C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Easton, Douglas F. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cai, Qiuyin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Long, Jirong | UNSPECIFIED | orcid.org/0000-0002-7433-9766 | UNSPECIFIED |
|
URN: |
urn:nbn:de:hbz:38-262328 |
DOI: |
10.1002/ijc.30150 |
Journal or Publication Title: |
Int. J. Cancer |
Volume: |
139 |
Number: |
6 |
Page Range: |
S. 1303 - 1318 |
Date: |
2016 |
Publisher: |
WILEY |
Place of Publication: |
HOBOKEN |
ISSN: |
1097-0215 |
Language: |
English |
Faculty: |
Unspecified |
Divisions: |
Unspecified |
Subjects: |
no entry |
Uncontrolled Keywords: |
Keywords | Language |
---|
GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; COLORECTAL-CANCER; ANALYSES REVEAL; GENE DESERT; C-MYC; EXPRESSION; FOXA1; AMPLIFICATION; DETERMINANT | Multiple languages | Oncology | Multiple languages |
|
Refereed: |
Yes |
URI: |
http://kups.ub.uni-koeln.de/id/eprint/26232 |
Downloads per month over past year
Export