Ensenauer, R., Hucklenbruch-Rother, E., Bruell, V. and Doetsch, J. (2016). Perinatal programming of type 2 diabetes mellitus. Diabetologe, 12 (6). S. 437 - 449. NEW YORK: SPRINGER. ISSN 1860-9724
Full text not available from this repository.Abstract
Early metabolic influences in utero increase the risk for metabolic imbalances such as type 2 diabetes mellitus in the offspring's later life, via mechanisms referred to as fetal programming. Important perinatal risk factors for metabolic alterations in later life are intrauterine growth restriction, preconception maternal obesity, and a diabetic intrauterine milieu. As shown in human studies and experimental animal models, maternal diabetes mellitus in pregnancy can induce various long-term consequences for organ function in the offspring. Underlying mechanisms of perinatal programming involve epigenetic processes. Consecutively, gene expression may be modified, and/or structural modifications can occur in the offspring. A more detailed understanding of the early-life origins of diabetes mellitus and prediabetes is required for the development of preventive concepts and early treatment strategies.
Item Type: | Journal Article | ||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-263996 | ||||||||||||||||||||
DOI: | 10.1007/s11428-016-0126-1 | ||||||||||||||||||||
Journal or Publication Title: | Diabetologe | ||||||||||||||||||||
Volume: | 12 | ||||||||||||||||||||
Number: | 6 | ||||||||||||||||||||
Page Range: | S. 437 - 449 | ||||||||||||||||||||
Date: | 2016 | ||||||||||||||||||||
Publisher: | SPRINGER | ||||||||||||||||||||
Place of Publication: | NEW YORK | ||||||||||||||||||||
ISSN: | 1860-9724 | ||||||||||||||||||||
Language: | German | ||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||
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Refereed: | Yes | ||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/26399 |
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