Universität zu Köln

Eichhorst, Barbara, Hallek, Michael and Goede, Valentin (2016). New treatment approaches in CLL: Challenges and opportunities in the elderly. J. Geriatr. Oncol., 7 (5). S. 375 - 383. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1879-4076

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Abstract

The majority of patients with chronic lymphocytic leukemia (CLL) are over 70 years old. These patients vary in their vulnerability toward treatment efforts. Heterogeneity in fitness of older patients with CLL is mainly determined by individual differences in physiological aging and pathological conditions such as comorbidities and geriatric syndromes. Various options exist to treat older patients with CLL outside and inside clinical trials. Among these are new treatment approaches, including chemoimmunotherapy with engineered CD20 antibodies (e.g., obinutuzumab), single agent therapy with Icinase inhibitors (e.g., ibrutinib, idelalisib), other targeted drug therapy (e.g., venetoclax, lenalidomide), and combinations of these novel compounds. Treatment recommendations for older patients take patient-related as well as disease-related risk factors into consideration. Emerging new treatment approaches in older patients offer novel opportunities, but also novel challenges which are discussed in this review. (C) 2016 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eichhorst, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Goede, Valentin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-264008
DOI:	10.1016/j.jgo.2016.07.007
Journal or Publication Title:	J. Geriatr. Oncol.
Volume:	7
Number:	5
Page Range:	S. 375 - 383
Date:	2016
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1879-4076
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHRONIC LYMPHOCYTIC-LEUKEMIA; PREVIOUSLY UNTREATED PATIENTS; RITUXIMAB REGIMEN; INITIAL THERAPY; OLDER PATIENTS; OPEN-LABEL; PHASE-3 TRIAL; CYCLOPHOSPHAMIDE; FLUDARABINE; CHLORAMBUCIL Multiple languages Oncology; Geriatrics & Gerontology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26400