Eichhorst, Barbara, Hallek, Michael and Goede, Valentin (2016). New treatment approaches in CLL: Challenges and opportunities in the elderly. J. Geriatr. Oncol., 7 (5). S. 375 - 383. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1879-4076
Full text not available from this repository.Abstract
The majority of patients with chronic lymphocytic leukemia (CLL) are over 70 years old. These patients vary in their vulnerability toward treatment efforts. Heterogeneity in fitness of older patients with CLL is mainly determined by individual differences in physiological aging and pathological conditions such as comorbidities and geriatric syndromes. Various options exist to treat older patients with CLL outside and inside clinical trials. Among these are new treatment approaches, including chemoimmunotherapy with engineered CD20 antibodies (e.g., obinutuzumab), single agent therapy with Icinase inhibitors (e.g., ibrutinib, idelalisib), other targeted drug therapy (e.g., venetoclax, lenalidomide), and combinations of these novel compounds. Treatment recommendations for older patients take patient-related as well as disease-related risk factors into consideration. Emerging new treatment approaches in older patients offer novel opportunities, but also novel challenges which are discussed in this review. (C) 2016 Elsevier Ltd. All rights reserved.
Item Type: | Journal Article | ||||||||||||||||
Creators: |
|
||||||||||||||||
URN: | urn:nbn:de:hbz:38-264008 | ||||||||||||||||
DOI: | 10.1016/j.jgo.2016.07.007 | ||||||||||||||||
Journal or Publication Title: | J. Geriatr. Oncol. | ||||||||||||||||
Volume: | 7 | ||||||||||||||||
Number: | 5 | ||||||||||||||||
Page Range: | S. 375 - 383 | ||||||||||||||||
Date: | 2016 | ||||||||||||||||
Publisher: | ELSEVIER SCIENCE BV | ||||||||||||||||
Place of Publication: | AMSTERDAM | ||||||||||||||||
ISSN: | 1879-4076 | ||||||||||||||||
Language: | English | ||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||
Subjects: | no entry | ||||||||||||||||
Uncontrolled Keywords: |
|
||||||||||||||||
Refereed: | Yes | ||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/26400 |
Downloads
Downloads per month over past year
Altmetric
Export
Actions (login required)
View Item |