Universität zu Köln

Maier, Franziska, Williamson, Kim L., Tahmasian, Masoud ORCID: 0000-0003-3999-3807, Rochhausen, Luisa, Ellereit, Anna L., Prigatano, George P., Kracht, Lutz, Tang, Chris C., Herz, Damian M., Fink, Gereon R. ORCID: 0000-0002-8230-1856, Timmermann, Lars and Eggers, Carsten (2016). Behavioural and neuroimaging correlates of impaired self-awareness of hypo- and hyperkinesia in Parkinson's disease. Cortex, 82. S. 35 - 48. PARIS: ELSEVIER MASSON, CORPORATION OFFICE. ISSN 1973-8102

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Abstract

Introduction: Anosognosia or impaired self-awareness of motor symptoms (ISAm) has been rarely investigated in Parkinson's disease (PD). We here studied the relationship between ISAm during periods with and without dopaminergic medication (ON- and OFF-state), and clinical, neuropsychological, and neuroimaging data to further elucidate behavioural aspects and the neurobiological underpinnings of ISAm. Methods: Thirty-one right-handed, non-demented, non-depressed PD patients were included. ISAm was evaluated using a recently developed scale that assesses awareness of dyskinesia, resting tremor, and bradykinesia. The test was applied during both ON- and OFF-states. Multiple correlation analyses between ISAm and behavioural data were conducted. In addition, imaging of glucose metabolism using 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) was performed to investigate the neural basis of ISAm. A multiple regression approach was applied to investigate metabolism alterations related to ISAm. Results: In the OFF-state, higher ISAm was associated with left-sided disease onset, older age, and shorter disease duration. Concerning FDG-PET data, there was a significant negative correlation between higher OFF-state ISAm and decreased glucose metabolism in the right inferior frontal gyrus (IFG). In the ON-state, ISAm was not significantly correlated with clinical or behavioural data. However, there was a significant correlation between higher ISAm and an increased metabolism in the bilateral medial frontal gyrus, left IFG, right superior frontal gyrus and right precentral gyrus. Conclusion: The results support the role of the right hemisphere in awareness of motor symptoms in the OFF-state. In the ON-state, dopaminergic medication and dyskinesia influence ISAm and relate to metabolism changes in bilateral frontal regions. (C) 2016 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Maier, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Williamson, Kim L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tahmasian, Masoud UNSPECIFIED orcid.org/0000-0003-3999-3807 UNSPECIFIED Rochhausen, Luisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Ellereit, Anna L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Prigatano, George P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kracht, Lutz UNSPECIFIED UNSPECIFIED UNSPECIFIED Tang, Chris C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Herz, Damian M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Eggers, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-265444
DOI:	10.1016/j.cortex.2016.05.019
Journal or Publication Title:	Cortex
Volume:	82
Page Range:	S. 35 - 48
Date:	2016
Publisher:	ELSEVIER MASSON, CORPORATION OFFICE
Place of Publication:	PARIS
ISSN:	1973-8102
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LEVODOPA-INDUCED DYSKINESIAS; ALZHEIMER-DISEASE; COGNITIVE CONTROL; ANOSOGNOSIA; UNAWARENESS; HEMIPLEGIA; BRAIN; FMRI; DEFICITS; CORTEX Multiple languages Behavioral Sciences; Neurosciences; Psychology, Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26544