Universität zu Köln

Leibovici, Leonard, Paul, Mical, Garner, Paul ORCID: 0000-0002-0607-6941, Sinclair, David J., Afshari, Arash, Pace, Nathan Leon, Cullum, Nicky ORCID: 0000-0003-2631-123X, Williams, Hywel C., Smyth, Alan ORCID: 0000-0001-5494-5438, Skoetz, Nicole, Del Mar, Chris ORCID: 0000-0003-3821-8163, Schilder, Anne G. M., Yahav, Dafna ORCID: 0000-0003-3181-9791 and Tovey, David (2016). Addressing resistance to antibiotics in systematic reviews of antibiotic interventions. J. Antimicrob. Chemother., 71 (9). S. 2367 - 2370. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2091

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Abstract

Antibiotics are among the most important interventions in healthcare. Resistance of bacteria to antibiotics threatens the effectiveness of treatment. Systematic reviews of antibiotic treatments often do not address resistance to antibiotics even when data are available in the original studies. This omission creates a skewed view, which emphasizes short-term efficacy and ignores the long-term consequences to the patient and other people. We offer a framework for addressing antibiotic resistance in systematic reviews. We suggest that the data on background resistance in the original trials should be reported and taken into account when interpreting results. Data on emergence of resistance (whether in the body reservoirs or in the bacteria causing infection) are important outcomes. Emergence of resistance should be taken into account when interpreting the evidence on antibiotic treatment in randomized controlled trials or systematic reviews.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Leibovici, Leonard UNSPECIFIED UNSPECIFIED UNSPECIFIED Paul, Mical UNSPECIFIED UNSPECIFIED UNSPECIFIED Garner, Paul UNSPECIFIED orcid.org/0000-0002-0607-6941 UNSPECIFIED Sinclair, David J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Afshari, Arash UNSPECIFIED UNSPECIFIED UNSPECIFIED Pace, Nathan Leon UNSPECIFIED UNSPECIFIED UNSPECIFIED Cullum, Nicky UNSPECIFIED orcid.org/0000-0003-2631-123X UNSPECIFIED Williams, Hywel C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Smyth, Alan UNSPECIFIED orcid.org/0000-0001-5494-5438 UNSPECIFIED Skoetz, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED Del Mar, Chris UNSPECIFIED orcid.org/0000-0003-3821-8163 UNSPECIFIED Schilder, Anne G. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yahav, Dafna UNSPECIFIED orcid.org/0000-0003-3181-9791 UNSPECIFIED Tovey, David UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-265663
DOI:	10.1093/jac/dkw135
Journal or Publication Title:	J. Antimicrob. Chemother.
Volume:	71
Number:	9
Page Range:	S. 2367 - 2370
Date:	2016
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1460-2091
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRIAL Multiple languages Infectious Diseases; Microbiology; Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26566