Universität zu Köln

Enders, P., Scholz, P., Muether, P. S. and Fauser, S. (2016). Variability of disease activity in patients treated with ranibizumab for neovascular age-related macular degeneration. Eye, 30 (8). S. 1072 - 1077. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5454

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Abstract

Purpose To analyze choroidal neovasularization (CNV) activity and recurrence patterns in patients with neovascular age-related macular degeneration (nAMD) treated with ranibizumab, and the correlation with individual intraocular vascular endothelial growth factor (VEGF) suppression time (VST). Methods Post-hoc analysis of data from a prospective, non-randomized clinical study. Patients with nAMD treated with ranibizumab on a pro re nata regimen. Disease activity was analyzed monthly by spectral-domain optical coherence tomography and correlated with VSTs. Results Overall, 73 eyes of 73 patients were included in the study with a mean follow-up of 717 days (range: 412-1239 days). Overall, the mean CNV-activity-free interval was 76.5 days (range: 0-829 days). The individual range of the length of dry intervals was high. A total of 42% of patients had a range of more than 90 days. Overall, 16% of patients showed persistent activity. And 12% stayed dry after the initial ranibizumab treatment. No significant correlation was found between the CNV-recurrence pattern and VST (P = 0.12). Conclusions CNV activity in nAMD is irregular, which is reflected in the range of the duration of dry intervals and late recurrences. The biomarker VST solely seems not to be sufficient to explain recurrence pattern of CNV in all AMD patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Enders, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scholz, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Muether, P. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-267320
DOI:	10.1038/eye.2016.97
Journal or Publication Title:	Eye
Volume:	30
Number:	8
Page Range:	S. 1072 - 1077
Date:	2016
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1476-5454
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENDOTHELIAL GROWTH-FACTOR; AQUEOUS-HUMOR LEVELS; ANTI-VEGF TREATMENT; DIABETIC-RETINOPATHY; VITREOUS LEVELS; BEVACIZUMAB; DELAY Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26732