Universität zu Köln

Chakupurakal, Geothy, Garcia-Marquez, Maria Alejandra ORCID: 0000-0002-5923-5942, Shimabukuro-Vornhagen, Alexander ORCID: 0000-0002-2351-7294, Theurich, Sebastian ORCID: 0000-0001-5706-8258, Holtick, Udo, Hallek, Michael, Scheid, Christof and von Bergwelt-Baildon, Michael (2016). Immunological effects in patients with steroid-refractory graft-versus-host disease following treatment with basiliximab, a CD25 monoclonal antibody. Eur. J. Haematol., 97 (2). S. 121 - 128. HOBOKEN: WILEY-BLACKWELL. ISSN 1600-0609

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Abstract

Steroid-refractory graft-versus-host disease (GvHD) is a complication following an allogeneic stem cell transplantation with limited therapeutic options. Studies have shown a response in up to 80% of patients with this condition after treatment with the CD25 monoclonal antibody, basiliximab. Despite the good responses to treatment, around 50% of the patients experience recurrence of their GvHD symptoms 4-6 wk following cessation of therapy. The in vivo changes in the following treatment with this antibody have not been elucidated so far. We treated 14 patients with severe steroid-refractory GvHD with basiliximab weekly for 4 wk and monitored the changes in the T-, B-, NK- and dendritic cell subsets over this time period. The overall response to treatment was 92% (13/14) with 50% (7/14) achieving a complete response. Fifty four percentage (7/13) of the patients who responded showed recurrence of their GvHD symptoms. Contrary to expectations, our observations showed a significant depletion of the regulatory T-cell subset following treatment. Our findings suggest that the undesirable depletion of the regulatory T cells along with the CD25+ acute inflammatory cells might be responsible for the high incidence of GvHD recurrence in this cohort of patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Chakupurakal, Geothy UNSPECIFIED UNSPECIFIED UNSPECIFIED Garcia-Marquez, Maria Alejandra UNSPECIFIED orcid.org/0000-0002-5923-5942 UNSPECIFIED Shimabukuro-Vornhagen, Alexander UNSPECIFIED orcid.org/0000-0002-2351-7294 UNSPECIFIED Theurich, Sebastian UNSPECIFIED orcid.org/0000-0001-5706-8258 UNSPECIFIED Holtick, Udo UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheid, Christof UNSPECIFIED UNSPECIFIED UNSPECIFIED von Bergwelt-Baildon, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-267569
DOI:	10.1111/ejh.12691
Journal or Publication Title:	Eur. J. Haematol.
Volume:	97
Number:	2
Page Range:	S. 121 - 128
Date:	2016
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1600-0609
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REGULATORY T-CELLS; RENAL-ALLOGRAFT RECIPIENTS; ACUTE CELLULAR REJECTION; INTERLEUKIN-2-RECEPTOR ANTAGONIST; PERIPHERAL-BLOOD; TRANSPLANTATION; ACTIVATION; MANAGEMENT; THERAPY; PHASE Multiple languages Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26756