Universität zu Köln

Mueller, Urs B. and Howard, Jonathan C. (2016). The impact of Toxoplasma gondii on the mammalian genome. Curr. Opin. Microbiol., 32. S. 19 - 26. LONDON: CURRENT BIOLOGY LTD. ISSN 1879-0364

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Abstract

Nobody doubts that infections have imposed specialisations on the mammalian genome. However sufficient information is usually missing to attribute a specific genomic modification to pressure from a specific pathogen. Recent studies on mechanisms of mammalian resistance against the ubiquitous protozoan parasite, Toxoplasma gondii, have shown that the small rodents presumed to be largely responsible for transmission of the parasite to its definitive host, the domestic cat, possess distinctive recognition proteins, and interferon inducible effector proteins (IRG proteins) that limit the potential virulence of the parasite. The phylogenetic association of the recognition proteins, TLR11 and TLR12, with T. gondii resistance is weak, but there is evidence for reciprocal polymorphism between parasite virulence proteins and host IRG proteins that strongly suggests current or recent coevolution.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mueller, Urs B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Howard, Jonathan C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-267856
DOI:	10.1016/j.mib.2016.04.009
Journal or Publication Title:	Curr. Opin. Microbiol.
Volume:	32
Page Range:	S. 19 - 26
Date:	2016
Publisher:	CURRENT BIOLOGY LTD
Place of Publication:	LONDON
ISSN:	1879-0364
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TOLL-LIKE RECEPTORS; NEOSPORA-CANINUM; INNATE IMMUNITY; RESISTANCE MECHANISM; POPULATION-STRUCTURE; APODEMUS-SYLVATICUS; HOST-DEFENSE; RISK-FACTORS; INFECTION; MICE Multiple languages Microbiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26785