Universität zu Köln

He, Fei, Arce, Agustin L., Schmitz, Gregor, Koornneef, Maarten ORCID: 0000-0002-7759-4869, Novikova, Polina, Beyer, Andreas ORCID: 0000-0002-3891-2123 and de Meaux, Juliette ORCID: 0000-0002-2942-4750 (2016). The Footprint of Polygenic Adaptation on Stress-Responsive Cis-Regulatory Divergence in the Arabidopsis Genus. Mol. Biol. Evol., 33 (8). S. 2088 - 2102. OXFORD: OXFORD UNIV PRESS. ISSN 1537-1719

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Abstract

Adaptation of a complex trait often requires the accumulation of many modifications to finely tune its underpinning molecular components to novel environmental requirements. The investigation of cis-acting regulatorymodifications can be used to pinpoint molecular systems partaking in such complex adaptations. Here, we identify cis-acting modifications with the help of an interspecific crossing scheme designed to distinguish modifications derived in each of the two sister species, Arabidopsis halleri and A. lyrata. Allele-specific expression levels were assessed in three environmental conditions chosen to reflect interspecific ecological differences: cold exposure, dehydration, and standard conditions. The functions described by Gene Ontology categories enriched in cis-acting mutations are markedly different in A. halleri and A. lyrata, suggesting that polygenic adaptation reshaped distinct polygenic molecular functions in the two species. In the A. halleri lineage, an excess of cis-acting changes affectingmetal transport and homeostasis was observed, confirming that the wellknown heavy metal tolerance of this species is the result of polygenic selection. In A. lyrata, we find amarked excess of cisacting changes among genes showing a transcriptional response to cold stress in the outgroup species A. thaliana. The adaptive relevance of these changes will have to be validated. We finally observed that polygenic molecular functions enriched in derived cis-acting changes are more constrained at the amino acid level. Using the distribution of cis-acting variation to tackle the polygenic basis of adaptation thus reveals the contribution of mutations of small effect to Darwinian adaptation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code He, Fei UNSPECIFIED UNSPECIFIED UNSPECIFIED Arce, Agustin L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitz, Gregor UNSPECIFIED UNSPECIFIED UNSPECIFIED Koornneef, Maarten UNSPECIFIED orcid.org/0000-0002-7759-4869 UNSPECIFIED Novikova, Polina UNSPECIFIED UNSPECIFIED UNSPECIFIED Beyer, Andreas UNSPECIFIED orcid.org/0000-0002-3891-2123 UNSPECIFIED de Meaux, Juliette UNSPECIFIED orcid.org/0000-0002-2942-4750 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-269027
DOI:	10.1093/molbev/msw096
Journal or Publication Title:	Mol. Biol. Evol.
Volume:	33
Number:	8
Page Range:	S. 2088 - 2102
Date:	2016
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1537-1719
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Botanical Institute
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CONTROLLING COMPLEX TRAITS; LOCAL ADAPTATION; GENETIC-BASIS; HALLERI BRASSICACEAE; SEMANTIC SIMILARITY; ZINC TOLERANCE; HIGH-SALINITY; R PACKAGE; EXPRESSION; EVOLUTION Multiple languages Biochemistry & Molecular Biology; Evolutionary Biology; Genetics & Heredity Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26902