Universität zu Köln

Engert, Andreas and Raemaekers, John (2016). Treatment of early-stage Hodgkin lymphoma. Semin. Hematol., 53 (3). S. 165 - 171. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC. ISSN 1532-8686

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Abstract

Hodgkin lymphoma (HL) has become one of the best curable malignancies today. This is particularly true for patients with early-stage disease. Today, most patients in this risk group are treated with a combination of chemotherapy followed by small-field radiotherapy. More recent clinical trials such as the German Hodgkin Study Group (GHSG) HD10 study demonstrated, that even two cycles of ABVD followed by 20 Gy involved-field radiation therapy (IF-RT) are sufficient and result in more than 90% of patients being cured. The current treatment for early unfavorable patients is either four cycles of ABVD plus 30 Gy IF-RT or two cycles of BEACOPP(baseline) followed by two cycles of ABVD plus IF-RT. Here, the European Organization for Research and Treatment of Cancer (EORTC) demonstrated that in positron emission tomography (PET)-positive patients after two cycles of ABVD, treatment switched to two cycles of P BEACOP(baseline) plus radiotherapy results in significantly improved outcomes. Other aspects including attempts to further reduce intensity of treatment will be discussed. (C) 2016 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Engert, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Raemaekers, John UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-270436
DOI:	10.1053/j.seminhematol.2016.05.004
Journal or Publication Title:	Semin. Hematol.
Volume:	53
Number:	3
Page Range:	S. 165 - 171
Date:	2016
Publisher:	W B SAUNDERS CO-ELSEVIER INC
Place of Publication:	PHILADELPHIA
ISSN:	1532-8686
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; INVOLVED-FIELD RADIOTHERAPY; PET-DIRECTED THERAPY; CARDIOVASCULAR-DISEASE; FINAL ANALYSIS; 2 CYCLES; FDG-PET; CHEMOTHERAPY; BLEOMYCIN; DACARBAZINE Multiple languages Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27043