Universität zu Köln

Veit, Johannes A., Heine, Daniela, Thierauf, Julia, Lennerz, Jochen, Shetty, Subasch, Schuler, Patrick J., Whiteside, Theresa, Beutner, Dirk, Meyer, Moritz, Gruenewald, Inga, Ritter, Gerd, Gnjatic, Sacha ORCID: 0000-0001-5643-9520, Sikora, Andrew G., Hoffmann, Thomas K. and Laban, Simon ORCID: 0000-0001-6732-7137 (2016). Expression and clinical significance of MAGE and NY-ESO-1 cancer-testis antigens in adenoid cystic carcinoma of the head and neck. Head Neck-J. Sci. Spec. Head Neck, 38 (7). S. 1008 - 1017. HOBOKEN: WILEY. ISSN 1097-0347

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Abstract

Background. Adenoid cystic carcinoma (ACC) of the head and neck is a rare but highly malignant tumor. Cancer-testis antigens (CTAs) represent an immunogenic family of cancer-specific proteins and thus represent an attractive target for immunotherapy. Methods. Eighty-four cases of ACC were identified, the CTAs pan-Melanoma antigen (pan-MAGE; M3H67) and New York esophageal squamous cell carcinoma (NY-ESO-1; E978) were detected immunohistochemically (IHC) and correlated with clinical data. Results. Expression of NY-ESO-1 was found in 48 of 84 patients (57.1%) and of pan-MAGE in 28 of 84 patients (31.2%). Median overall survival (OS) in NY-ESO-1 positive versus negative patients was 130.8 and 282.0 months (p = .223), respectively. OS in pan-MAGE positive versus negative patients was 105.3 and 190.5 months, respectively (p=.096). Patients expressing both NY-ESO-1 and pan-MAGE simultaneously had significantly reduced OS with a median of 90.5 months compared with 282.0 months in negative patients (p=.047). Conclusion. A significant fraction of patients with ACC show expression of the CTAs NY-ESO-1 and/or pan-MAGE with promising immunotherapeutic implications. (C) 2016 Wiley Periodicals, Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Veit, Johannes A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heine, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Thierauf, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Lennerz, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Shetty, Subasch UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuler, Patrick J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Whiteside, Theresa UNSPECIFIED UNSPECIFIED UNSPECIFIED Beutner, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Moritz UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruenewald, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED Ritter, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Gnjatic, Sacha UNSPECIFIED orcid.org/0000-0001-5643-9520 UNSPECIFIED Sikora, Andrew G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Thomas K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Laban, Simon UNSPECIFIED orcid.org/0000-0001-6732-7137 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-270640
DOI:	10.1002/hed.24403
Journal or Publication Title:	Head Neck-J. Sci. Spec. Head Neck
Volume:	38
Number:	7
Page Range:	S. 1008 - 1017
Date:	2016
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0347
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SQUAMOUS-CELL CARCINOMA; TUMOR-INFILTRATING LYMPHOCYTES; MELANOMA PATIENTS; OROPHARYNGEAL CANCER; METASTATIC MELANOMA; PROTEIN VACCINATION; CTLA-4 BLOCKADE; MYELOMA CELLS; IMMUNE-SYSTEM; LUNG-CANCER Multiple languages Otorhinolaryngology; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27064