Salama, Mahmoud ORCID: 0000-0002-0282-8018, Isachenko, Vladimir, Isachenko, Evgenia, Rahimi, Gohar and Mallmann, Peter (2016). Updates in preserving reproductive potential of prepubertal girls with cancer: Systematic review. Crit. Rev. Oncol./Hematol., 103. S. 10 - 22. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1879-0461

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Abstract

Introduction: With increasing numbers of adult female survivors of childhood cancers due to advances in early diagnosis and treatment, the issue of preserving the reproductive potential of prepubertal girls undergoing gonadotoxic treatments has gained greater attention. Methods: According to PRISMA guidelines, a systematic review of the literature was performed for all relevant full-text articles published in PubMed in English throughout the past 15 years to explore the significant updates in preserving the reproductive potential of prepubertal girls with cancer. Results: The two established fertility preservation options, embryo freezing and egg freezing, cannot be offered routinely to prepubertal girls as these options necessitate prior ovarian stimulation and subsequent mature oocytes retrieval that are contraindicated or infeasible before puberty. Therefore, the most suitable fertility preservation options to prepubertal girls are (1) ovarian tissue freezing and autotransplantation, (2) in vitro maturation, and (3) ovarian protection techniques. In this review, we discuss in detail those options as well as their success rates, advantages, disadvantages and future directions. We also suggest a new integrated strategy to preserve the reproductive potential of prepubertal girls with cancer. Conclusion: Although experimental, ovarian tissue slow freezing and orthotopic autotransplantation may be the most feasible option to preserve the reproductive potential of prepubertal girls with cancer. However, this technique has two major and serious disadvantages: (1) the risk of reintroducing malignant cells, and (2) the relatively short lifespan of ovarian tissue transplants. Several medical and ethical considerations should be taken into account before applying this technique to prepubertal girls with cancer. (C) 2016 Published by Elsevier Ireland Ltd.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Salama, MahmoudUNSPECIFIEDorcid.org/0000-0002-0282-8018UNSPECIFIED
Isachenko, VladimirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Isachenko, EvgeniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rahimi, GoharUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mallmann, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-271377
DOI: 10.1016/j.critrevonc.2016.04.002
Journal or Publication Title: Crit. Rev. Oncol./Hematol.
Volume: 103
Page Range: S. 10 - 22
Date: 2016
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1879-0461
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CRYOPRESERVED OVARIAN TISSUE; IN-VITRO MATURATION; PRE-ANTRAL FOLLICLES; FERTILITY PRESERVATION; BREAST-CANCER; CHILDHOOD-CANCER; PROTECTING OVARIES; GONAD SUPPRESSION; YOUNG-WOMEN; LIVE BIRTHMultiple languages
Oncology; HematologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/27137

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