Universität zu Köln

Kribs, Angela and Hummler, Helmut (2016). Ancillary therapies to enhance success of non-invasive modes of respiratory support - Approaches to delivery room use of surfactant and caffeine? Semin. Fetal Neonatal Med., 21 (3). S. 212 - 219. OXFORD: ELSEVIER SCI LTD. ISSN 1878-0946

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Abstract

During recent decades, non-invasive respiratory support has become popular for treating neonates with respiratory failure. Several prospective randomized controlled trials have been performed to compare use of continuous positive airway pressure (CPAP) as primary respiratory support in preterm infants with respiratory distress syndrome (RDS) to endotracheal intubation, mechanical ventilation and surfactant therapy. Systematic reviews of these studies suggest that routine CPAP at delivery is efficacious in decreasing bronchopulmonary dysplasia (BPD), death, or both. This led to the recommendation to consider CPAP to avoid endotracheal intubation. As surfactant therapy is known to reduce BPD and death, several ways to combine CPAP with surfactant have been described. With the increasing use of CPAP immediately after birth, the early use of caffeine to stimulate respiration has become a point of discussion. This review focuses on different modes of surfactant application during CPAP and on the early use of caffeine as ancillary therapies to enhance CPAP success. (C) 2016 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kribs, Angela UNSPECIFIED UNSPECIFIED UNSPECIFIED Hummler, Helmut UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-273105
DOI:	10.1016/j.siny.2016.02.011
Journal or Publication Title:	Semin. Fetal Neonatal Med.
Volume:	21
Number:	3
Page Range:	S. 212 - 219
Date:	2016
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1878-0946
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXTREMELY PREMATURE-INFANTS; RANDOMIZED CONTROLLED-TRIAL; BREATHING PRETERM INFANTS; DISTRESS-SYNDROME; LESS-THAN-OR-EQUAL-TO-27 WEEKS; INTUBATION; OUTCOMES; BIRTH; METAANALYSIS; VENTILATION Multiple languages Pediatrics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27310