Deckert, Martina, Brunn, Anna, Montesinos-Rongen, Manuel and Siebert, Reiner (2016). Absence of Lymphatic Vessels in PCNSL May Contribute to Confinement of Tumor Cells to the Central Nervous System. J. Neuropathol. Exp. Neurol., 75 (6). S. 499 - 503. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 0022-3069
Full text not available from this repository.Abstract
Primary central nervous system (CNS) lymphoma (PCNSL) is a mature lymphoma of the diffuse large B-cell lymphoma (DLBCL) type confined to the CNS. Despite cytomorphological similarities between PCNSL and systemic DLBCL, molecular differences between both entities have been identified. The exclusively topographical restriction of PCNSL to the CNS is an unexplained mystery. To address the question of whether the unique lymphatic drainage system of the CNS, which differs from that of other organs, may play a role for this peculiar behavior, we investigated a series of 20 PCNSLs for the presence of lymphatic vessels by immunohistochemistry for Lyve-1, podoplanin, and Prox-1 expression. All PCNSLs lacked lymphatic vessels and, in this regard, were similar to 20 glioblastoma multiforme samples. In contrast to these tumors, all of which were located in the deep brain parenchyma, dural and meningeal DLBCL harbored lymphatic vessels that expressed Lyve-1 (3/8 tumors), podoplanin (5/8 tumors), and Prox-1 (5/8 tumors) in areas where the tumors had invaded the fibrous tissue of the dura. These data indicate that local topographical characteristics of the specific lymphatic drainage system may contribute to confinement of the tumor cells in PCNSL and malignant gliomas.
| Item Type: | Journal Article | ||||||||||||||||||||
| Creators: |
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| URN: | urn:nbn:de:hbz:38-273471 | ||||||||||||||||||||
| DOI: | 10.1093/jnen/nlw027 | ||||||||||||||||||||
| Journal or Publication Title: | J. Neuropathol. Exp. Neurol. | ||||||||||||||||||||
| Volume: | 75 | ||||||||||||||||||||
| Number: | 6 | ||||||||||||||||||||
| Page Range: | S. 499 - 503 | ||||||||||||||||||||
| Date: | 2016 | ||||||||||||||||||||
| Publisher: | LIPPINCOTT WILLIAMS & WILKINS | ||||||||||||||||||||
| Place of Publication: | PHILADELPHIA | ||||||||||||||||||||
| ISSN: | 0022-3069 | ||||||||||||||||||||
| Language: | English | ||||||||||||||||||||
| Faculty: | Unspecified | ||||||||||||||||||||
| Divisions: | Unspecified | ||||||||||||||||||||
| Subjects: | no entry | ||||||||||||||||||||
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| Refereed: | Yes | ||||||||||||||||||||
| URI: | http://kups.ub.uni-koeln.de/id/eprint/27347 |
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