Universität zu Köln

Bey, Katharina, Wolfsgruber, Steffen, Karaca, Ilker ORCID: 0000-0002-2139-0015, Wagner, Holger, Lardenoije, Roy, Becker, Julian, Milz, Esther, Kornhuber, Johannes ORCID: 0000-0002-8096-3987, Peters, Oliver, Froelich, Lutz, Huell, Michael, Ruether, Eckart, Wiltfang, Jens ORCID: 0000-0003-1492-5330, Riedel-Heller, Steffi, Scherer, Martin, Jessen, Frank, Maier, Wolfgang, van den Hove, Daniel L., Rutten, Bart P. F., Wagner, Michael ORCID: 0000-0003-2589-6440 and Ramirez, Alfredo ORCID: 0000-0003-4991-763X (2016). No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment. Epigenomics, 8 (5). S. 593 - 599. LONDON: FUTURE MEDICINE LTD. ISSN 1750-192X

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Abstract

Alterations in DNA methylation have been associated with cognitive decline and Alzheimer's disease. A recent study of mild cognitive impairment (MCI) reported a significant association between annual decline in cognitive function and the rs11887120 SNP located in DNMT3A, a gene implicated in DNA methylation. Here, we aimed to replicate this finding in two independent MCI cohorts (n = 1024); however, no significant association was observed in either cohort or the pooled dataset. In stratified analyses for conversion to Alzheimer's disease status, no association between rs11887120 and cognitive decline was observed in either converters or nonconverters. In conclusion, our analyses provide no support for the hypothesis that genetic variants in DNMT3A are implicated in cognitive performance decline in individuals with MCI.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bey, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolfsgruber, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Karaca, Ilker UNSPECIFIED orcid.org/0000-0002-2139-0015 UNSPECIFIED Wagner, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Lardenoije, Roy UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Milz, Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED Kornhuber, Johannes UNSPECIFIED orcid.org/0000-0002-8096-3987 UNSPECIFIED Peters, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Froelich, Lutz UNSPECIFIED UNSPECIFIED UNSPECIFIED Huell, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruether, Eckart UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiltfang, Jens UNSPECIFIED orcid.org/0000-0003-1492-5330 UNSPECIFIED Riedel-Heller, Steffi UNSPECIFIED UNSPECIFIED UNSPECIFIED Scherer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED van den Hove, Daniel L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rutten, Bart P. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED Ramirez, Alfredo UNSPECIFIED orcid.org/0000-0003-4991-763X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-276606
DOI:	10.2217/epi-2015-0014
Journal or Publication Title:	Epigenomics
Volume:	8
Number:	5
Page Range:	S. 593 - 599
Date:	2016
Publisher:	FUTURE MEDICINE LTD
Place of Publication:	LONDON
ISSN:	1750-192X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EPIGENETIC MECHANISMS; ALZHEIMERS-DISEASE; DNA METHYLATION; DIAGNOSIS; DEMENTIA; GERMAN Multiple languages Genetics & Heredity Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27660