Universität zu Köln

Moenig, S. P. and Schiffmann, L. M. (2016). Resection of advanced esophagogastric adenocarcinoma. Extended indications. Chirurg, 87 (5). S. 398 - 406. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0385

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Abstract

In the current German S3 guidelines surgical treatment is not recommended for metastatic gastric cancer or metastatic adenocarcinoma of the esophagogastric junction; however, in routine practice the indications can be extended so that there may be occasions in which radical surgical intervention for specific individuals may be appropriate as part of a multimodal therapy with curative intent. This article presents the scientific rationale of such an approach based on the available literature considering modern, multimodal therapy concepts including criteria to be met for radical surgery. Currently only retrospective trials and limited current meta-analysis data are available for justifying surgical treatment for metastatic adenocarcinoma. The recently published initial results of the FLOT-3 study identified a patient subgroup that benefits from a resection even though metastasis has occurred. Whether surgical therapy will become an integral part of the treatment of limited metastatic adenocarcinoma of the stomach and esophagus in the future, has to be demonstrated by large prospective randomized studies, such as the RENAISSANCE/FLOT-5 study.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Moenig, S. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiffmann, L. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-276782
DOI:	10.1007/s00104-016-0183-4
Journal or Publication Title:	Chirurg
Volume:	87
Number:	5
Page Range:	S. 398 - 406
Date:	2016
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0385
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SQUAMOUS-CELL CARCINOMA; GASTRIC-CANCER PATIENTS; LIVER METASTASES; PERIOPERATIVE CHEMOTHERAPY; PERITONEAL CARCINOMATOSIS; PHASE-II; GASTROESOPHAGEAL ADENOCARCINOMA; PREOPERATIVE CHEMOTHERAPY; NEOADJUVANT CHEMOTHERAPY; PALLIATIVE GASTRECTOMY Multiple languages Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27678