Universität zu Köln

Eichhorst, Barbara and Hallek, Michael (2016). Novel therapy concepts for chronic lymphocytic leukemia. Onkologe, 22 (4). S. 283 - 293. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0415

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Abstract

Chronic lymphocytic leukemia (CLL) is the most common form of leukemia in the western hemisphere and affects mainly elderly and male patients. There is currently no curative approach for advanced symptomatic stages of the disease despite great progress in treatment. Treatment is determined according to patient fitness and comorbidity burden as well as the presence of deletions or mutations in the TP53 gene (very high risk CLL). In physically fit patients without a high comorbidity burden and without very high risk prognostic factors intensive chemotherapy in combination with the CD20 antibody is the standard first line therapy, while in patients with a significant comorbidity burden a less intensive immunochemotherapy regimen is applied. In very high risk patients as well as in patients with relapsed CLL two oral kinase inhibitors, which block the signaling transduction pathway of the B cell receptor have been approved; however, in relapsed CLL repeat administration of immunochemotherapy is still an alternative treatment option, especially if the first remission period was of longer duration (> 24 months). Allogeneic hematopoietic stem cell transplantation can be considered in high risk CLL patients with insufficient response to kinase inhibitors.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eichhorst, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-279572
DOI:	10.1007/s00761-016-0024-6
Journal or Publication Title:	Onkologe
Volume:	22
Number:	4
Page Range:	S. 283 - 293
Date:	2016
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0415
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PREVIOUSLY UNTREATED PATIENTS; STEM-CELL TRANSPLANTATION; OPEN-LABEL; CLL; MULTICENTER; RITUXIMAB; SURVIVAL; CHLORAMBUCIL; OBINUTUZUMAB; IBRUTINIB Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27957