Universität zu Köln

Tian, Feng, Han, Yong, Song, Jian, Lei, Jie, Yan, Xiaolong ORCID: 0000-0003-2419-9707, Xie, Nianlin, Wang, Jian, Zhao, Jinbo, Liang, Xiaohua, Zhong, Daixing, Zhou, Yongan, Wang, Xiaoping and Li, Xiaofei (2016). Pulmonary resident neutrophils regulate the production of GM-CSF and alveolar macrophages. FEBS J., 283 (8). S. 1465 - 1475. HOBOKEN: WILEY. ISSN 1742-4658

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Abstract

Alveolar macrophages exist in the lung airspaces, and their differentiation and function are considerably regulated by the microenvironment. In this study, we examine the important role of resident neutrophil/IL-23/granulocyte/macrophage colony-stimulating factor (GM-CSF) axis in the development and preferential phenotype of alveolar macrophages under physiological conditions. Using CD18-deficient (CD18(-/-)) mice, we show a correlation between increased granulopoiesis and enhanced alveolar macrophage development in an IL-23- and GM-CSF-dependent manner. The apoptotic neutrophils could inhibit the secretion of IL-23 from alveolar macrophages, which is important for the production of GM-CSF, and depletion of neutrophils disrupted the regulation of IL-23 and GM-CSF. This study reveals a mechanism for the regulation of the local alveolar macrophage population and function by neutrophil apoptosis in the circulatory system.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tian, Feng UNSPECIFIED UNSPECIFIED UNSPECIFIED Han, Yong UNSPECIFIED UNSPECIFIED UNSPECIFIED Song, Jian UNSPECIFIED UNSPECIFIED UNSPECIFIED Lei, Jie UNSPECIFIED UNSPECIFIED UNSPECIFIED Yan, Xiaolong UNSPECIFIED orcid.org/0000-0003-2419-9707 UNSPECIFIED Xie, Nianlin UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Jian UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhao, Jinbo UNSPECIFIED UNSPECIFIED UNSPECIFIED Liang, Xiaohua UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhong, Daixing UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhou, Yongan UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Xiaoping UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Xiaofei UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-279720
DOI:	10.1111/febs.13684
Journal or Publication Title:	FEBS J.
Volume:	283
Number:	8
Page Range:	S. 1465 - 1475
Date:	2016
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1742-4658
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COLONY-STIMULATING FACTOR; INNATE LYMPHOID-CELLS; FETAL MONOCYTES; GRANULOPOIESIS; PHAGOCYTOSIS; HOMEOSTASIS; FIBROSIS; IL-23; GAMMA; LUNG Multiple languages Biochemistry & Molecular Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27972