Couch, Fergus J., Kuchenbaecker, Karoline B., Michailidou, Kyriaki ORCID: 0000-0001-7065-1237, Mendoza-Fandino, Gustavo A., Nord, Silje ORCID: 0000-0002-3271-5356, Lilyquist, Janna, Olswold, Curtis, Hallberg, Emily, Agata, Simona, Ahsan, Habibul, Aittomaeki, Kristiina, Ambrosone, Christine, Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker ORCID: 0000-0001-9320-8684, Arun, Banu K., Arver, Brita, Barile, Monica, Barkardottir, Rosa B., Barrowdale, Daniel ORCID: 0000-0003-1661-3939, Beckmann, Lars, Beckmann, Matthias W., Benitez, Javier, Blank, Stephanie V., Blomqvist, Carl ORCID: 0000-0003-3041-1938, Bogdanova, Natalia V., Bojesen, Stig E., Bolla, Manjeet K., Bonanni, Bernardo, Brauch, Hiltrud ORCID: 0000-0001-7531-2736, Brenner, Hermann ORCID: 0000-0002-6129-1572, Burwinkel, Barbara, Buys, Saundra S., Caldes, Trinidad, Caligo, Maria A., Canzian, Federico ORCID: 0000-0002-4261-4583, Carpenter, Jane, Chang-Claude, Jenny, Chanock, Stephen J., Chung, Wendy K., Claes, Kathleen B. M., Cox, Angela ORCID: 0000-0002-5138-1099, Cross, Simon S., Cunningham, Julie M., Czene, Kamila, Daly, Mary B., Damiola, Francesca ORCID: 0000-0002-0238-1252, Darabi, Hatef, de la Hoya, Miguel ORCID: 0000-0002-8113-1410, Devilee, Peter ORCID: 0000-0002-8023-2009, Diez, Orland, Ding, Yuan C., Dolcetti, Riccardo ORCID: 0000-0003-1625-9853, Domchek, Susan M., Dorfling, Cecilia M., dos-Santos-Silva, Isabel, Dumont, Martine, Dunning, Alison M., Eccles, Diana M., Ehrencrona, Hans ORCID: 0000-0002-5589-3622, Ekici, Arif B., Eliassen, Heather, Ellis, Steve, Fasching, Peter A., Figueroa, Jonine, Flesch-Janys, Dieter, Foersti, Asta, Fostira, Florentia, Foulkes, William D., Friebel, Tara ORCID: 0000-0002-3726-9527, Friedman, Eitan, Frost, Debra, Gabrielson, Marike ORCID: 0000-0002-3171-1556, Gammon, Marilie D., Ganz, Patricia A., Gapstur, Susan M., Garber, Judy, Gaudet, Mia M., Gayther, Simon A., Gerdes, Anne-Marie ORCID: 0000-0002-0328-3320, Ghoussaini, Maya, Giles, Graham G., Glendon, Gord, Godwin, Andrew K., Goldberg, Mark S., Goldgar, David E., Gonzalez-Neira, Anna ORCID: 0000-0002-5421-2020, Greene, Mark H., Gronwald, Jacek ORCID: 0000-0002-3643-2871, Guenel, Pascal ORCID: 0000-0002-8359-518X, Gunter, Marc, Haeberle, Lothar, Haiman, Christopher A., Hamann, Ute, Hansen, Thomas V. O., Hart, Steven ORCID: 0000-0001-7714-2734, Healey, Sue, Heikkinen, Tuomas ORCID: 0000-0003-1154-6204, Henderson, Brian E., Herzog, Josef, Hogervorst, Frans B. L., Hollestelle, Antoinette, Hooning, Maartje J., Hoover, Robert N., Hopper, John L., Humphreys, Keith, Hunter, David J., Huzarski, Tomasz ORCID: 0000-0003-3857-4854, Imyanitov, Evgeny N., Isaacs, Claudine, Jakubowska, Anna ORCID: 0000-0002-5650-0501, James, Paul ORCID: 0000-0002-4361-4657, Janavicius, Ramunas, Jensen, Uffe Birk ORCID: 0000-0002-6205-6355, John, Esther M., Jones, Michael ORCID: 0000-0001-7479-3451, Kabisch, Maria, Kar, Siddhartha, Karlan, Beth Y., Khan, Sofia ORCID: 0000-0003-4185-8882, Khaw, Kay-Tee, Kibriya, Muhammad G., Knight, Julia A., Ko, Yon-Dschun, Konstantopoulou, Irene ORCID: 0000-0002-0470-0309, Kosma, Veli-Matti, Kristensen, Vessela, Kwong, Ava ORCID: 0000-0002-6968-9489, Laitman, Yael, Lambrechts, Diether ORCID: 0000-0002-3429-302X, Lazaro, Conxi, Lee, Eunjung, Le Marchand, Loic, Lester, Jenny, Lindblom, Annika, Lindor, Noralane, Lindstrom, Sara, Liu, Jianjun ORCID: 0000-0002-3255-3019, Long, Jirong ORCID: 0000-0002-7433-9766, Lubinski, Jan ORCID: 0000-0003-2931-3003, Mai, Phuong L., Makalic, Enes, Malone, Kathleen E., Mannermaa, Arto, Manoukian, Siranoush, Margolin, Sara, Marme, Frederik, Martens, John W. M., McGuffog, Lesley, Meindl, Alfons, Miller, Austin, Milne, Roger L., Miron, Penelope, Montagna, Marco, Mazoyer, Sylvie ORCID: 0000-0002-2135-0160, Mulligan, Anna M., Muranen, Taru A., Nathanson, Katherine L., Neuhausen, Susan L., Nevanlinna, Heli, Nordestgaard, Borge G., Nussbaum, Robert L., Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I., Olson, Janet E., Osorio, Ana ORCID: 0000-0001-8124-3984, Park, Sue K., Peeters, Petra H., Peissel, Bernard ORCID: 0000-0001-9233-3571, Peterlongo, Paolo ORCID: 0000-0001-6951-6855, Peto, Julian, Phelan, Catherine M., Pilarski, Robert, Poppe, Bruce, Pylkaes, Katri, Radice, Paolo ORCID: 0000-0001-6298-4111, Rahman, Nazneen ORCID: 0000-0003-4376-0440, Rantala, Johanna, Rappaport, Christine, Rennert, Gad, Richardson, Andrea, Robson, Mark, Romieu, Isabelle, Rudolph, Anja, Rutgers, Emiel J., Sanchez, Maria-Jose, Santella, Regina M., Sawyer, Elinor J., Schmidt, Daniel F., Schmidt, Marjanka K., Schmutzler, Rita K., Schumacher, Fredrick ORCID: 0000-0002-3073-7463, Scott, Rodney, Senter, Leigha, Sharma, Priyanka ORCID: 0000-0001-8592-2239, Simard, Jacques, Singer, Christian F., Sinilnikova, Olga M., Soucy, Penny, Southey, Melissa ORCID: 0000-0002-6313-9005, Steinemann, Doris, Stenmark-Askmalm, Marie, Stoppa-Lyonnet, Dominique, Swerdlow, Anthony ORCID: 0000-0001-5550-4159, Szabo, Csilla I., Tamimi, Rulla, Tapper, William, Teixeira, Manuel R., Teo, Soo-Hwang, Terry, Mary B., Thomassen, Mads, Thompson, Deborah, Tihomirova, Laima, Toland, Amanda E., Tollenaar, Robert A. E. M., Tomlinson, Ian, Truong, Therese, Tsimiklis, Helen, Teule, Alex ORCID: 0000-0003-0028-7200, Tumino, Rosario, Tung, Nadine, Turnbull, Clare, Ursin, Giski, van Deurzen, Carolien H. M., van Rensburg, Elizabeth J., Varon-Mateeva, Raymonda, Wang, Zhaoming ORCID: 0000-0001-7556-3869, Wang-Gohrke, Shan, Weiderpass, Elisabete ORCID: 0000-0003-2237-0128, Weitzel, Jeffrey N., Whittemore, Alice, Wildiers, Hans, Winqvist, Robert, Yang, Xiaohong R., Yannoukakos, Drakoulis ORCID: 0000-0001-7509-3510, Yao, Song ORCID: 0000-0001-9442-1313, Zamora, M. Pilar, Zheng, Wei ORCID: 0000-0003-1226-070X, Hall, Per, Kraft, Peter ORCID: 0000-0002-4472-8103, Vachon, Celine, Slager, Susan, Chenevix-Trench, Georgia ORCID: 0000-0002-1878-2587, Pharoah, Paul D. P., Monteiro, Alvaro A. N., Garcia-Closas, Montserrat, Easton, Douglas F. and Antoniou, Antonis C.
(2016).
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer.
Nat. Commun., 7.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 2041-1723
Full text not available from this repository.
Abstract
Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 x 10(-8)) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 BRCA1 mutation carriers genotyped on the iCOGS array. We identify four previously unidentified loci including two loci at 13q22 near KLF5, a 2p23.2 locus near WDR43 and a 2q33 locus near PPIL3 that display genome-wide significant associations with ER-negative breast cancer. In addition, 19 known breast cancer risk loci have genome-wide significant associations and 40 had moderate associations (P<0.05) with ER-negative disease. Using functional and eQTL studies we implicate TRMT61B and WDR43 at 2p23.2 and PPIL3 at 2q33 in ER-negative breast cancer aetiology. All ER-negative loci combined account for similar to 11% of familial relative risk for ER-negative disease and may contribute to improved ER-negative and BRCA1 breast cancer risk prediction.
Item Type: |
Journal Article
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Creators: |
Creators | Email | ORCID | ORCID Put Code |
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Couch, Fergus J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kuchenbaecker, Karoline B. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Michailidou, Kyriaki | UNSPECIFIED | orcid.org/0000-0001-7065-1237 | UNSPECIFIED | Mendoza-Fandino, Gustavo A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nord, Silje | UNSPECIFIED | orcid.org/0000-0002-3271-5356 | UNSPECIFIED | Lilyquist, Janna | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Olswold, Curtis | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hallberg, Emily | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Agata, Simona | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ahsan, Habibul | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Aittomaeki, Kristiina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ambrosone, Christine | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Andrulis, Irene L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Anton-Culver, Hoda | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Arndt, Volker | UNSPECIFIED | orcid.org/0000-0001-9320-8684 | UNSPECIFIED | Arun, Banu K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Arver, Brita | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Barile, Monica | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Barkardottir, Rosa B. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Barrowdale, Daniel | UNSPECIFIED | orcid.org/0000-0003-1661-3939 | UNSPECIFIED | Beckmann, Lars | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Beckmann, Matthias W. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Benitez, Javier | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Blank, Stephanie V. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Blomqvist, Carl | UNSPECIFIED | orcid.org/0000-0003-3041-1938 | UNSPECIFIED | Bogdanova, Natalia V. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bojesen, Stig E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bolla, Manjeet K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bonanni, Bernardo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Brauch, Hiltrud | UNSPECIFIED | orcid.org/0000-0001-7531-2736 | UNSPECIFIED | Brenner, Hermann | UNSPECIFIED | orcid.org/0000-0002-6129-1572 | UNSPECIFIED | Burwinkel, Barbara | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Buys, Saundra S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Caldes, Trinidad | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Caligo, Maria A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Canzian, Federico | UNSPECIFIED | orcid.org/0000-0002-4261-4583 | UNSPECIFIED | Carpenter, Jane | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chang-Claude, Jenny | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chanock, Stephen J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chung, Wendy K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Claes, Kathleen B. M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cox, Angela | UNSPECIFIED | orcid.org/0000-0002-5138-1099 | UNSPECIFIED | Cross, Simon S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cunningham, Julie M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Czene, Kamila | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Daly, Mary B. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Damiola, Francesca | UNSPECIFIED | orcid.org/0000-0002-0238-1252 | UNSPECIFIED | Darabi, Hatef | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | de la Hoya, Miguel | UNSPECIFIED | orcid.org/0000-0002-8113-1410 | UNSPECIFIED | Devilee, Peter | UNSPECIFIED | orcid.org/0000-0002-8023-2009 | UNSPECIFIED | Diez, Orland | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ding, Yuan C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dolcetti, Riccardo | UNSPECIFIED | orcid.org/0000-0003-1625-9853 | UNSPECIFIED | Domchek, Susan M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dorfling, Cecilia M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | dos-Santos-Silva, Isabel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dumont, Martine | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dunning, Alison M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Eccles, Diana M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ehrencrona, Hans | UNSPECIFIED | orcid.org/0000-0002-5589-3622 | UNSPECIFIED | Ekici, Arif B. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Eliassen, Heather | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ellis, Steve | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fasching, Peter A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Figueroa, Jonine | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Flesch-Janys, Dieter | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Foersti, Asta | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fostira, Florentia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Foulkes, William D. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Friebel, Tara | UNSPECIFIED | orcid.org/0000-0002-3726-9527 | UNSPECIFIED | Friedman, Eitan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Frost, Debra | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gabrielson, Marike | UNSPECIFIED | orcid.org/0000-0002-3171-1556 | UNSPECIFIED | Gammon, Marilie D. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ganz, Patricia A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gapstur, Susan M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Garber, Judy | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gaudet, Mia M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gayther, Simon A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gerdes, Anne-Marie | UNSPECIFIED | orcid.org/0000-0002-0328-3320 | UNSPECIFIED | Ghoussaini, Maya | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Giles, Graham G. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Glendon, Gord | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Godwin, Andrew K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Goldberg, Mark S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Goldgar, David E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gonzalez-Neira, Anna | UNSPECIFIED | orcid.org/0000-0002-5421-2020 | UNSPECIFIED | Greene, Mark H. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gronwald, Jacek | UNSPECIFIED | orcid.org/0000-0002-3643-2871 | UNSPECIFIED | Guenel, Pascal | UNSPECIFIED | orcid.org/0000-0002-8359-518X | UNSPECIFIED | Gunter, Marc | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Haeberle, Lothar | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Haiman, Christopher A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hamann, Ute | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hansen, Thomas V. 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URN: |
urn:nbn:de:hbz:38-280647 |
DOI: |
10.1038/ncomms11375 |
Journal or Publication Title: |
Nat. Commun. |
Volume: |
7 |
Date: |
2016 |
Publisher: |
NATURE PUBLISHING GROUP |
Place of Publication: |
LONDON |
ISSN: |
2041-1723 |
Language: |
English |
Faculty: |
Unspecified |
Divisions: |
Unspecified |
Subjects: |
no entry |
Uncontrolled Keywords: |
Keywords | Language |
---|
GENOME-WIDE ASSOCIATION; BRCA2 MUTATION CARRIERS; GENE-EXPRESSION; COMMON VARIANTS; TELOMERE LENGTH; RISK; IDENTIFY; INVESTIGATORS; METAANALYSIS; CONSORTIUM | Multiple languages | Multidisciplinary Sciences | Multiple languages |
|
Refereed: |
Yes |
URI: |
http://kups.ub.uni-koeln.de/id/eprint/28064 |
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