Eibach, Daniel, Al-Emran, Hassan M., Dekker, Denise Myriam, Krumkamp, Ralf, Adu-Sarkodie, Yaw, Espinoza, Ligia Maria Cruz, Ehmen, Christa, Boahen, Kennedy, Heisig, Peter, Im, Justin, Jaeger, Anna, von Kalckreuth, Vera, Pak, Gi Deok, Panzner, Ursula, Park, Se Eun, Reinhardt, Alexander, Sarpong, Nimako, Schuett-Gerowitt, Heidi, Wierzba, Thomas F., Marks, Florian ORCID: 0000-0002-6043-7170 and May, Juergen (2016). The Emergence of Reduced Ciprofloxacin Susceptibility in Salmonella enterica Causing Bloodstream Infections in Rural Ghana. Clin. Infect. Dis., 62. S. S32 - 5. CARY: OXFORD UNIV PRESS INC. ISSN 1537-6591

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Abstract

Methods.aEuro integral From May 2007 until May 2012, children attending a rural district hospital in central Ghana were eligible for recruitment. Salmonella enterica isolated from blood cultures were assessed for ciprofloxacin susceptibility by Etest (susceptible minimum inhibitory concentration [MIC] a parts per thousand currency sign 0.06 A mu g/mL). The gyrA, gyrB, parC, and parE genes were sequenced to identify mutations associated with changes in susceptibility to fluoroquinolones. Results.aEuro integral Two hundred eighty-five Salmonella enterica isolates from 5211 blood cultures were most commonly identified as Salmonella enterica serovar Typhimurium (n = 129 [45%]), Salmonella enterica serovar Typhi (n = 89 [31%]), Salmonella enterica serovar Dublin (n = 20 [7%]), and Salmonella enterica serovar Enteritidis (n = 19 [7%]). All S. Typhi and S. Dublin were susceptible to ciprofloxacin. Reduced susceptibility (MIC > 0.06 A mu g/mL) was found in 53% (10/19) of S. Enteritidis and in 2% (3/129) of S. Typhimurium isolates. Sequencing detected a single gyrB mutation (Glu466Asp) and a single gyrA mutation (Ser83Tyr) in all 3 S. Typhimurium isolates, while 9 of 10 S. Enteritidis harbored single gyrA mutations (Asp87Gly, Asp87Asn, or Asp87Tyr). No mutations were found in the parC and parE genes. Conclusions.aEuro integral Ciprofloxacin susceptibility in invasive NTS in rural Ghana is highly dependent on serotype. Although reduced ciprofloxacin susceptibility is low in S. Typhimurium, more than half of all S. Enteritidis isolates are affected. Healthcare practitioners in Ghana should be aware of potential treatment failure in patients with invasive S. Enteritidis infections.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Eibach, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Al-Emran, Hassan M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dekker, Denise MyriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krumkamp, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adu-Sarkodie, YawUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Espinoza, Ligia Maria CruzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ehmen, ChristaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boahen, KennedyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heisig, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Im, JustinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaeger, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Kalckreuth, VeraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pak, Gi DeokUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Panzner, UrsulaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Park, Se EunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reinhardt, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sarpong, NimakoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schuett-Gerowitt, HeidiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wierzba, Thomas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marks, FlorianUNSPECIFIEDorcid.org/0000-0002-6043-7170UNSPECIFIED
May, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-281390
DOI: 10.1093/cid/civ757
Journal or Publication Title: Clin. Infect. Dis.
Volume: 62
Page Range: S. S32 - 5
Date: 2016
Publisher: OXFORD UNIV PRESS INC
Place of Publication: CARY
ISSN: 1537-6591
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ANTIMICROBIAL DRUG-RESISTANCE; SEROVAR-TYPHI; AFRICA; ENTERITIDIS; CHILDREN; DISEASE; ADULTS; QEPA; QNRMultiple languages
Immunology; Infectious Diseases; MicrobiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/28139

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