Universität zu Köln

Kluge, Regine, Chavdarova, Lidia, Hoffmann, Martha, Kobe, Carsten, Malkowski, Bogdan ORCID: 0000-0003-1421-4694, Montravers, Francoise, Kurch, Lars, Georgi, Thomas, Dietlein, Markus, Wallace, W. Hamish, Karlen, Jonas, Fernandez-Teijeiro, Ana, Cepelova, Michaela, Wilson, Lorrain, Bergstraesser, Eva, Sabri, Osama ORCID: 0000-0002-6425-3504, Mauz-Koerholz, Christine, Koerholz, Dieter and Hasenclever, Dirk (2016). Inter-Reader Reliability of Early FDG-PET/CT Response Assessment Using the Deauville Scale after 2 Cycles of Intensive Chemotherapy (OEPA) in Hodgkin's Lymphoma. PLoS One, 11 (3). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Purpose The five point Deauville (D) scale is widely used to assess interim PET metabolic response to chemotherapy in Hodgkin lymphoma (HL) patients. An International Validation Study reported good concordance among reviewers in ABVD treated advanced stage HL patients for the binary discrimination between score D1,2,3 and score D4,5. Inter-reader reliability of the whole scale is not well characterised. Methods Five international expert readers scored 100 interim PET/CT scans from paediatric HL patients. Scans were acquired in 51 European hospitals after two courses of OEPA chemotherapy (according to the EuroNet-PHL-C1 study). Images were interpreted in direct comparison with staging PET/CTs. Results The probability that two random readers concord on the five point D score of a random case is only 42% (global kappa = 0.24). Aggregating to a three point scale D1,2 vs. D3 vs. D4,5 improves concordance to 60% (kappa = 0.34). Concordance if one of two readers assigns a given score is 70% for score D1,2 only 36% for score D3 and 64% for D4,5. Concordance for the binary decisions D1,2 vs. D3,4,5 is 67% and 86% for D1,2,3 vs D4,5 (kappa = 0.36 resp. 0.56). If one reader assigns D1,2,3 concordance probability is 92%, but only 64% if D4,5 is called. Discrepancies occur mainly in mediastinum, neck and skeleton. Conclusion Inter-reader reliability of the five point D-scale is poor in this interobserver analysis of paediatric patients who underwent OEPA. Inter-reader variability is maximal in cases assigned to D2 or D3. The binary distinction D1,2,3 versus D4,5 is the most reliable criterion for clinical decision making.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kluge, Regine UNSPECIFIED UNSPECIFIED UNSPECIFIED Chavdarova, Lidia UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Martha UNSPECIFIED UNSPECIFIED UNSPECIFIED Kobe, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Malkowski, Bogdan UNSPECIFIED orcid.org/0000-0003-1421-4694 UNSPECIFIED Montravers, Francoise UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurch, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Georgi, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietlein, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Wallace, W. Hamish UNSPECIFIED UNSPECIFIED UNSPECIFIED Karlen, Jonas UNSPECIFIED UNSPECIFIED UNSPECIFIED Fernandez-Teijeiro, Ana UNSPECIFIED UNSPECIFIED UNSPECIFIED Cepelova, Michaela UNSPECIFIED UNSPECIFIED UNSPECIFIED Wilson, Lorrain UNSPECIFIED UNSPECIFIED UNSPECIFIED Bergstraesser, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Sabri, Osama UNSPECIFIED orcid.org/0000-0002-6425-3504 UNSPECIFIED Mauz-Koerholz, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Koerholz, Dieter UNSPECIFIED UNSPECIFIED UNSPECIFIED Hasenclever, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-281618
DOI:	10.1371/journal.pone.0149072
Journal or Publication Title:	PLoS One
Volume:	11
Number:	3
Date:	2016
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; INTERNATIONAL WORKSHOP; MULTICENTER TRIALS; CRITERIA; CONCORDANCE; GUIDELINES; ONCOLOGY; THERAPY; NETWORK; FRANCE Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28161