Universität zu Köln

Bagatell, Rochelle, McHugh, Kieran, Naranjo, Arlene, Van Ryn, Collin, Kirby, Chaim, Brock, Penelope, Lyons, Karen A., States, Lisa J., Rojas, Yesenia, Miller, Alexandra, Volchenboum, Sam L., Simon, Thorsten, Krug, Barbara, Sarnacki, Sabine ORCID: 0000-0003-4304-5578, Valteau-Couanet, Dominique, von Schweinitz, Dietrich, Kammer, Birgit, Granata, Claudio ORCID: 0000-0003-3072-4096, Pio, Luca ORCID: 0000-0002-3776-9994, Park, Julie R. and Nuchtern, Jed (2016). Assessment of Primary Site Response in Children With High-Risk Neuroblastoma: An International Multicenter Study. J. Clin. Oncol., 34 (7). S. 740 - 749. ALEXANDRIA: AMER SOC CLINICAL ONCOLOGY. ISSN 1527-7755

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Abstract

Purpose The International Neuroblastoma Response Criteria (INRC) require serial measurements of primary tumors in three dimensions, whereas the Response Evaluation Criteria in Solid Tumors (RECIST) require measurement in one dimension. This study was conducted to identify the preferred method of primary tumor response assessment for use in revised INRC. Patients and Methods Patients younger than 20 years with high-risk neuroblastoma were eligible if they were diagnosed between 2000 and 2012 and if three primary tumor measurements (antero-posterior, width, cranio-caudal) were recorded at least twice before resection. Responses were defined as >= 30% reduction in longest dimension as per RECIST, >= 50% reduction in volume as per INRC, or >= 65% reduction in volume. Results Three-year event-free survival for all patients (N = 229) was 44% and overall survival was 58%. The sensitivity of both volume response measures (ability to detect responses in patients who survived) exceeded the sensitivity of the single dimension measure, but the specificity of all response measures (ability to identify lack of response in patients who later died) was low. In multivariable analyses, none of the response measures studied was predictive of outcome, and none was predictive of the extent of resection. Conclusion None of the methods of primary tumor response assessment was predictive of outcome. Measurement of three dimensions followed by calculation of resultant volume is more complex than measurement of a single dimension. Primary tumor response in children with high-risk neuroblastoma should therefore be evaluated in accordance with RECIST criteria, using the single longest dimension. (C) 2016 by American Society of Clinical Oncology

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bagatell, Rochelle UNSPECIFIED UNSPECIFIED UNSPECIFIED McHugh, Kieran UNSPECIFIED UNSPECIFIED UNSPECIFIED Naranjo, Arlene UNSPECIFIED UNSPECIFIED UNSPECIFIED Van Ryn, Collin UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirby, Chaim UNSPECIFIED UNSPECIFIED UNSPECIFIED Brock, Penelope UNSPECIFIED UNSPECIFIED UNSPECIFIED Lyons, Karen A. UNSPECIFIED UNSPECIFIED UNSPECIFIED States, Lisa J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rojas, Yesenia UNSPECIFIED UNSPECIFIED UNSPECIFIED Miller, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Volchenboum, Sam L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Krug, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Sarnacki, Sabine UNSPECIFIED orcid.org/0000-0003-4304-5578 UNSPECIFIED Valteau-Couanet, Dominique UNSPECIFIED UNSPECIFIED UNSPECIFIED von Schweinitz, Dietrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Kammer, Birgit UNSPECIFIED UNSPECIFIED UNSPECIFIED Granata, Claudio UNSPECIFIED orcid.org/0000-0003-3072-4096 UNSPECIFIED Pio, Luca UNSPECIFIED orcid.org/0000-0002-3776-9994 UNSPECIFIED Park, Julie R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuchtern, Jed UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-282210
DOI:	10.1200/JCO.2015.63.2042
Journal or Publication Title:	J. Clin. Oncol.
Volume:	34
Number:	7
Page Range:	S. 740 - 749
Date:	2016
Publisher:	AMER SOC CLINICAL ONCOLOGY
Place of Publication:	ALEXANDRIA
ISSN:	1527-7755
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STAGE 4 NEUROBLASTOMA; BEAM-RADIATION-THERAPY; INDUCTION CHEMOTHERAPY; EVALUATION CRITERIA; TUMOR VOLUME; DIAGNOSIS; IMPACT; TRIAL Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28221