Bagatell, Rochelle, McHugh, Kieran, Naranjo, Arlene, Van Ryn, Collin, Kirby, Chaim, Brock, Penelope, Lyons, Karen A., States, Lisa J., Rojas, Yesenia, Miller, Alexandra, Volchenboum, Sam L., Simon, Thorsten, Krug, Barbara, Sarnacki, Sabine ORCID: 0000-0003-4304-5578, Valteau-Couanet, Dominique, von Schweinitz, Dietrich, Kammer, Birgit, Granata, Claudio ORCID: 0000-0003-3072-4096, Pio, Luca ORCID: 0000-0002-3776-9994, Park, Julie R. and Nuchtern, Jed (2016). Assessment of Primary Site Response in Children With High-Risk Neuroblastoma: An International Multicenter Study. J. Clin. Oncol., 34 (7). S. 740 - 749. ALEXANDRIA: AMER SOC CLINICAL ONCOLOGY. ISSN 1527-7755

Full text not available from this repository.

Abstract

Purpose The International Neuroblastoma Response Criteria (INRC) require serial measurements of primary tumors in three dimensions, whereas the Response Evaluation Criteria in Solid Tumors (RECIST) require measurement in one dimension. This study was conducted to identify the preferred method of primary tumor response assessment for use in revised INRC. Patients and Methods Patients younger than 20 years with high-risk neuroblastoma were eligible if they were diagnosed between 2000 and 2012 and if three primary tumor measurements (antero-posterior, width, cranio-caudal) were recorded at least twice before resection. Responses were defined as >= 30% reduction in longest dimension as per RECIST, >= 50% reduction in volume as per INRC, or >= 65% reduction in volume. Results Three-year event-free survival for all patients (N = 229) was 44% and overall survival was 58%. The sensitivity of both volume response measures (ability to detect responses in patients who survived) exceeded the sensitivity of the single dimension measure, but the specificity of all response measures (ability to identify lack of response in patients who later died) was low. In multivariable analyses, none of the response measures studied was predictive of outcome, and none was predictive of the extent of resection. Conclusion None of the methods of primary tumor response assessment was predictive of outcome. Measurement of three dimensions followed by calculation of resultant volume is more complex than measurement of a single dimension. Primary tumor response in children with high-risk neuroblastoma should therefore be evaluated in accordance with RECIST criteria, using the single longest dimension. (C) 2016 by American Society of Clinical Oncology

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bagatell, RochelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McHugh, KieranUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Naranjo, ArleneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van Ryn, CollinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kirby, ChaimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brock, PenelopeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lyons, Karen A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
States, Lisa J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rojas, YeseniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miller, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Volchenboum, Sam L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simon, ThorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krug, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sarnacki, SabineUNSPECIFIEDorcid.org/0000-0003-4304-5578UNSPECIFIED
Valteau-Couanet, DominiqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Schweinitz, DietrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kammer, BirgitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Granata, ClaudioUNSPECIFIEDorcid.org/0000-0003-3072-4096UNSPECIFIED
Pio, LucaUNSPECIFIEDorcid.org/0000-0002-3776-9994UNSPECIFIED
Park, Julie R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nuchtern, JedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-282210
DOI: 10.1200/JCO.2015.63.2042
Journal or Publication Title: J. Clin. Oncol.
Volume: 34
Number: 7
Page Range: S. 740 - 749
Date: 2016
Publisher: AMER SOC CLINICAL ONCOLOGY
Place of Publication: ALEXANDRIA
ISSN: 1527-7755
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
STAGE 4 NEUROBLASTOMA; BEAM-RADIATION-THERAPY; INDUCTION CHEMOTHERAPY; EVALUATION CRITERIA; TUMOR VOLUME; DIAGNOSIS; IMPACT; TRIALMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/28221

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item