Universität zu Köln

Heidenreich, A. and Boehmer, D. (2016). Multimodal therapy of locally advanced prostate cancer. Urologe, 55 (3). S. 333 - 345. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0563

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Abstract

Locally advanced prostate cancer (LAPCA) comprises about 5-10 % of all newly diagnosed prostate cancers and is associated with the highest prostate cancer specific mortality (approximately 8-20 %). LAPCA is defined by the presence of extraprostatic extension, seminal vesicle invasion, and bladder neck infiltration of pelvic lymph node metastases. It is evident that prognosis can only be improved by interdisciplinary multimodality treatment strategies. Adequate local staging by multiparametric MRI is one of the cornerstones for an individualized, risk-adapted treatment approach. This might consist of extended radical prostatectomy with an extended pelvic lymphadenectomy or intensity-modulated radiation therapy with androgen deprivation as the primary local therapeutic approach. Both treatment strategies may be combined with neoadjuvant or adjuvant radiation therapy or salvage surgery. Combination with neoadjuvant or adjuvant chemotherapy and new androgen receptor pathway inhibitors might also be possible. This article summarizes the current treatment strategies for LAPCA.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heidenreich, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boehmer, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-283077
DOI:	10.1007/s00120-016-0046-0
Journal or Publication Title:	Urologe
Volume:	55
Number:	3
Page Range:	S. 333 - 345
Date:	2016
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0563
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANDROGEN-DEPRIVATION THERAPY; PHASE-III TRIAL; SALVAGE RADIATION-THERAPY; POSITIVE SURGICAL MARGIN; TERM-FOLLOW-UP; RADICAL PROSTATECTOMY; GETUG 12; EXTRAPROSTATIC EXTENSION; EXTRACAPSULAR EXTENSION; PELVIC LYMPHADENECTOMY Multiple languages Urology & Nephrology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28307