Universität zu Köln

Backes, Heiko, Walberer, Maureen, Ladwig, Anne, Rueger, Maria A., Neumaier, Bernd ORCID: 0000-0001-5425-3116, Endepols, Heike ORCID: 0000-0002-6166-4818, Hoehn, Mathias, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Schroeter, Michael and Graf, Rudolf (2016). Glucose consumption of inflammatory cells masks metabolic deficits in the brain. Neuroimage, 128. S. 54 - 63. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-9572

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Abstract

Inflammatory cells such as microglia need energy to exert their functions and to maintain their cellular integrity and membrane potential. Subsequent to cerebral ischemia, inflammatory cells infiltrate tissue with limited blood flow where neurons and astrocytes died due to insufficient supply with oxygen and glucose. Using dual tracer positron emission tomography (PET), we found that concomitant with the presence of inflammatory cells, transport and consumption of glucose increased up to normal levels but returned to pathological levels as soon as inflammatory cells disappeared. Thus, inflammatory cells established sufficient glucose supply to satisfy their energy demands even in regions with insufficient supply for neurons and astrocytes to survive. Our data suggest that neurons and astrocytes died from oxygen deficiency and inflammatory cells metabolized glucose non-oxidatively in regions with residual availability. As a consequence, glucose metabolism of inflammatory cells can mask metabolic deficits in neurodegenerative diseases. We further found that the PET tracer did not bind to inflammatory cells in severely hypoperfused regions and thus only a part of the inflammation was detected. We conclude that glucose consumption of inflammatory cells should be taken into account when analyzing disease-related alterations of local cerebral metabolism. (C) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Backes, Heiko UNSPECIFIED UNSPECIFIED UNSPECIFIED Walberer, Maureen UNSPECIFIED UNSPECIFIED UNSPECIFIED Ladwig, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Rueger, Maria A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumaier, Bernd UNSPECIFIED orcid.org/0000-0001-5425-3116 UNSPECIFIED Endepols, Heike UNSPECIFIED orcid.org/0000-0002-6166-4818 UNSPECIFIED Hoehn, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Schroeter, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Graf, Rudolf UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-284000
DOI:	10.1016/j.neuroimage.2015.12.044
Journal or Publication Title:	Neuroimage
Volume:	128
Page Range:	S. 54 - 63
Date:	2016
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-9572
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MICROGLIAL ACTIVATION; REFERENCE TISSUE; PET; STROKE; QUANTIFICATION; ISCHEMIA; RECEPTOR; DISEASE; MODEL Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28400