Universität zu Köln

van Kooten, Maria J., Veldhuizen, Maria G., de Araujo, Ivan E., O'Malley, Stephanie S. and Small, Dana M. (2016). Fatty acid amide supplementation decreases impulsivity in young adult heavy drinkers. Physiol. Behav., 155. S. 131 - 141. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 0031-9384

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Abstract

Compromised dopamine signaling in the striatum has been associated with the expression of impulsive behaviors in addiction, obesity and alcoholism. In rodents, intragastric infusion of the fatty acid amide oleoylethanolamide increases striatal extracellular dopamine levels via vagal afferent signaling. Here we tested whether supplementation with PhosphoLean (TM), a dietary supplement that contains the precursor of the fatty acid amide oleoylethanolamide (N-oleyl-phosphatidylethanolamine), would reduce impulsive responding and alcohol use in heavy drinking young adults. Twenty-two individuals were assigned to a three-week supplementation regimen with PhosphoLean (TM) or placebo. Impulsivity was assessed with self -report questionnaires and behavioral tasks pre- and post-supplementation. Although self-report measures of impulsivity did not change, supplementation with PhosphoLean (TM), but not placebo, significantly reduced false alarm rate on a Go/No-Go task. In addition, an association was found between improved sensitivity on the Go/No-Go task and reduced alcohol intake. These findings provide preliminary evidence that promoting fatty acid derived gut-brain dopamine communication may have therapeutic potential for reducing impulsivity in heavy drinkers. (C) 2015 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code van Kooten, Maria J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Veldhuizen, Maria G. UNSPECIFIED UNSPECIFIED UNSPECIFIED de Araujo, Ivan E. UNSPECIFIED UNSPECIFIED UNSPECIFIED O'Malley, Stephanie S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Small, Dana M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-284161
DOI:	10.1016/j.physbeh.2015.11.032
Journal or Publication Title:	Physiol. Behav.
Volume:	155
Page Range:	S. 131 - 141
Date:	2016
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	0031-9384
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language N-ACYLETHANOLAMINE LEVELS; DIETARY-FAT; STRIATAL RESPONSE; FOOD; OBESITY; RELIABILITY; VALIDITY; BEHAVIOR; SATIETY; BRAIN Multiple languages Psychology, Biological; Behavioral Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28416