Universität zu Köln

Er, Fikret, Dahlem, Kristina M., Nia, Amir M., Erdmann, Erland, Waltenberger, Johannes, Hellmich, Martin, Kuhr, Kathrin, Le, Minh Tam, Herrfurth, Tina, Taghiyev, Zulfugar, Biesenbach, Esther, Yueksel, Dilek, Eran-Ergoeknil, Aslihan, Vanezi, Maria, Caglayan, Evren and Gassanov, Natig (2016). Randomized Control of Sympathetic Drive With Continuous Intravenous Esmolol in Patients With Acute ST-Segment Elevation Myocardial Infarction The BEtA-Blocker Therapy in Acute Myocardial Infarction (BEAT-AMI) Trial. JACC-Cardiovasc. Interv., 9 (3). S. 231 - 241. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1876-7605

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Abstract

OBJECTIVES This study sought to evaluate the role of esmolol-induced tight sympathetic control in patients with ST-segment elevation myocardial infarction (STEMI). BACKGROUND Elevated sympathetic drive has a detrimental effect on patients with acute STEMI. The effect of beta-blocker-induced heart rate mediated sympathetic control on myocardial damage is unknown. METHODS The authors conducted a prospective, randomized, single-blind trial involving patients with STEMI and successful percutaneous intervention (Killip class I and II). Patients were randomly allocated to heart rate control with intravenous esmolol for 24 h or placebo. The primary outcome was the maximum change in troponin T release as a prognostic surrogate marker for myocardial damage. A total of 101 patients were enrolled in the study.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Er, Fikret UNSPECIFIED UNSPECIFIED UNSPECIFIED Dahlem, Kristina M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nia, Amir M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Erdmann, Erland UNSPECIFIED UNSPECIFIED UNSPECIFIED Waltenberger, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhr, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Le, Minh Tam UNSPECIFIED UNSPECIFIED UNSPECIFIED Herrfurth, Tina UNSPECIFIED UNSPECIFIED UNSPECIFIED Taghiyev, Zulfugar UNSPECIFIED UNSPECIFIED UNSPECIFIED Biesenbach, Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED Yueksel, Dilek UNSPECIFIED UNSPECIFIED UNSPECIFIED Eran-Ergoeknil, Aslihan UNSPECIFIED UNSPECIFIED UNSPECIFIED Vanezi, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Caglayan, Evren UNSPECIFIED UNSPECIFIED UNSPECIFIED Gassanov, Natig UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-284706
DOI:	10.1016/j.jcin.2015.10.035
Journal or Publication Title:	JACC-Cardiovasc. Interv.
Volume:	9
Number:	3
Page Range:	S. 231 - 241
Date:	2016
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1876-7605
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PERCUTANEOUS CORONARY INTERVENTION; BRAIN NATRIURETIC PEPTIDE; LEFT-VENTRICULAR FUNCTION; CARDIAC TROPONIN-I; CREATINE KINASE-MB; HEART-RATE CONTROL; PLASMA-CATECHOLAMINES; CLINICAL-OUTCOMES; SERUM BIOMARKERS; PROGNOSTIC VALUE Multiple languages Cardiac & Cardiovascular Systems Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28470