Universität zu Köln

Rebensburg, Stephanie, Helfer, Markus, Schneider, Martha, Koppensteiner, Herwig, Eberle, Josef, Schindler, Michael ORCID: 0000-0001-8989-5813, Guertler, Lutz and Brack-Werner, Ruth (2016). Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins. Sci Rep, 6. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

Novel therapeutic options are urgently needed to improve global treatment of virus infections. Herbal products with confirmed clinical safety features are attractive starting material for the identification of new antiviral activities. Here we demonstrate that Cistus incanus (Ci) herbal products inhibit human immunodeficiency virus (HIV) infections in vitro. Ci extract inhibited clinical HIV-1 and HIV-2 isolates, and, importantly, a virus isolate with multiple drug resistances, confirming broad anti-HIV activity. Antiviral activity was highly selective for virus particles, preventing primary attachment of the virus to the cell surface and viral envelope proteins from binding to heparin. Bioassay-guided fractionation indicated that Ci extract contains numerous antiviral compounds and therefore has favorably low propensity to induce virus resistance. Indeed, no resistant viruses emerged during 24 weeks of continuous propagation of the virus in the presence of Ci extracts. Finally, Ci extracts also inhibited infection by virus particles pseudotyped with Ebola and Marburg virus envelope proteins, indicating that antiviral activity of Ci extract extends to emerging viral pathogens. These results demonstrate that Ci extracts show potent and broad in vitro antiviral activity against viruses that cause life-threatening diseases in humans and are promising sources of agents that target virus particles.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rebensburg, Stephanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Helfer, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Martha UNSPECIFIED UNSPECIFIED UNSPECIFIED Koppensteiner, Herwig UNSPECIFIED UNSPECIFIED UNSPECIFIED Eberle, Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED Schindler, Michael UNSPECIFIED orcid.org/0000-0001-8989-5813 UNSPECIFIED Guertler, Lutz UNSPECIFIED UNSPECIFIED UNSPECIFIED Brack-Werner, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-284830
DOI:	10.1038/srep20394
Journal or Publication Title:	Sci Rep
Volume:	6
Date:	2016
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN-IMMUNODEFICIENCY-VIRUS; HEPARAN-SULFATE; NATURAL-PRODUCTS; PHENOLIC-COMPOUNDS; MEDICINAL-PLANTS; DRUG DISCOVERY; ATTACHMENT; INFECTION; ENTRY; REPLICATION Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28483