Grajewski, Rafael S., Bosch, Jacobus J., Bruns, Heiko, Cursiefen, Claus and Heindl, Ludwig M. (2016). The Trojan Horse Tale Revisited: An Eye on Metastatic Spread of Carcinoma Cells. Cancer Immunol. Res., 4 (2). S. 92 - 95. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 2326-6074
Full text not available from this repository.Abstract
The metastatic spread of carcinoma cells is not fully understood. Here, we compare the peripheral blood mononuclear cells (PBMC) and intraocular metastatic cells in parotid gland carcinoma with the PBMCs of healthy donors by immunohistochemistry and flow cytometry. We found Ber-EP4 tumor marker-positive carcinoma cells in the aqueous humor of the patient's right eye and a CD45 and Ber-EP4-expressing PBMC population in his blood. These Ber-EP4-expressing cells exhibited a mono-cytic-myeloid phenotype with coexpression of CD11b, CD115, and the macrophage marker CD172a (SIRP-alpha). Uptake of pHrodogreen revealed their phagocytic activity. Our findings suggest that the tumor cells in the anterior chamber originally derived from cell fusions between tumor cells and myeloid cells in the peripheral blood. Thus, metastases of a solid malignancy could use monocytes-macrophages as the Trojan horse to enter the eye. (C) 2015 AACR.
| Item Type: | Journal Article | ||||||||||||||||||||||||
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| URN: | urn:nbn:de:hbz:38-284969 | ||||||||||||||||||||||||
| DOI: | 10.1158/2326-6066.CIR-15-0127 | ||||||||||||||||||||||||
| Journal or Publication Title: | Cancer Immunol. Res. | ||||||||||||||||||||||||
| Volume: | 4 | ||||||||||||||||||||||||
| Number: | 2 | ||||||||||||||||||||||||
| Page Range: | S. 92 - 95 | ||||||||||||||||||||||||
| Date: | 2016 | ||||||||||||||||||||||||
| Publisher: | AMER ASSOC CANCER RESEARCH | ||||||||||||||||||||||||
| Place of Publication: | PHILADELPHIA | ||||||||||||||||||||||||
| ISSN: | 2326-6074 | ||||||||||||||||||||||||
| Language: | English | ||||||||||||||||||||||||
| Faculty: | Unspecified | ||||||||||||||||||||||||
| Divisions: | Unspecified | ||||||||||||||||||||||||
| Subjects: | no entry | ||||||||||||||||||||||||
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| Refereed: | Yes | ||||||||||||||||||||||||
| URI: | http://kups.ub.uni-koeln.de/id/eprint/28496 |
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