Universität zu Köln

Heuser, Sandra, Hufbauer, Martin, Marx, Benjamin, Tok, Ali, Majewski, Slawomir, Pfister, Herbert and Akguel, Baki (2016). The levels of epithelial anchor proteins beta-catenin and zona occludens-1 are altered by E7 of human papillomaviruses 5 and 8. J. Gen. Virol., 97. S. 463 - 473. LONDON: MICROBIOLOGY SOC. ISSN 1465-2099

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Abstract

Infection with viruses of the genus Betapapillomavirus, beta-human papillomaviruses (beta-HPV), is implicated in the development of non-melanoma skin cancer. This was first evidenced for HPV5 and HPV8 in patients with the skin disease epidermodysplasia verruciformis (EV). The relocalization of the junctional bridging proteins beta-catenin and zona occludens-1 (ZO-1) from the adherens and tight junctions are common processes of the epithelial-mesenchymal transition (EMT) associated with tumour invasion. Here, we report that beta-catenin and ZO-1 are strongly upregulated by the E7 oncoproteins of HPV5 and HPV8 in keratinocytes grown in organotypic skin cultures. Although the membrane-tethered form of beta-catenin was elevated, no signs of beta-catenin activity within the canonical Wnt signalling pathway could be detected. The upregulation of beta-catenin and ZO-1 could also be confirmed in the skin of HPV8 transgenic mice as well as in cutaneous squamous cell carcinomas of EV patients. These data provide the first evidence that beta-catenin and ZO-1 are direct targets of E7 of the oncogenic beta-HPV types 5 and 8. The ability to deregulate these epithelial junction proteins may contribute to the oncogenic potential of these viruses in human skin.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heuser, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Hufbauer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Marx, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED Tok, Ali UNSPECIFIED UNSPECIFIED UNSPECIFIED Majewski, Slawomir UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfister, Herbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Akguel, Baki UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-285117
DOI:	10.1099/jgv.0.000363
Journal or Publication Title:	J. Gen. Virol.
Volume:	97
Page Range:	S. 463 - 473
Date:	2016
Publisher:	MICROBIOLOGY SOC
Place of Publication:	LONDON
ISSN:	1465-2099
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TIGHT JUNCTION PROTEINS; EPIDERMODYSPLASIA-VERRUCIFORMIS; EARLY GENES; SKIN; KERATINOCYTES; INVASION; CANCER; ZO-1; HPV; DIFFERENTIATION Multiple languages Biotechnology & Applied Microbiology; Virology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28511