Universität zu Köln

Cooper, Cyrus, Bardin, Thomas ORCID: 0000-0002-5080-4790, Brandi, Maria-Luisa, Cacoub, Patrice ORCID: 0000-0002-6727-4992, Caminis, John, Civitelli, Roberto ORCID: 0000-0003-4076-4315, Cutolo, Maurizio, Dere, Willard, Devogelaer, Jean-Pierre, Diez-Perez, Adolfo ORCID: 0000-0001-8162-0209, Einhorn, Thomas A., Emonts, Patrick, Ethgen, Olivier, Kanis, John A., Kaufman, Jean-Marc, Kvien, Tore K., Lems, Willem F., McCloskey, Eugene, Miossec, Pierre, Reiter, Susanne, Ringe, Johann, Rizzoli, Rene, Saag, Kenneth and Reginster, Jean-Yves (2016). Balancing benefits and risks of glucocorticoids in rheumatic diseases and other inflammatory joint disorders: new insights from emerging data. An expert consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Aging Clin. Exp. Res., 28 (1). S. 1 - 17. NEW YORK: SPRINGER. ISSN 1720-8319

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Abstract

This consensus review article considers the question of whether glucocorticoid (GC) therapy is still relevant in the treatment of rheumatic diseases, with a particular focus on rheumatoid arthritis (RA), and whether its side effects can be adequately managed. Recent basic and clinical research on the molecular, cellular and clinical effects of GCs have considerably advanced our knowledge in this field. An overview of the subject seems appropriate. This review is the result of a multidisciplinary expert working group, organised by European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis. The recent literature was surveyed and the salient evidence synthetized. The pathophysiological basis of RA (and other inflammatory rheumatic diseases) now strongly implicates the adaptive immune system in addition to innate mechanisms. The molecular effect of GCs and differential GC sensitivity is better understood, although exploiting this knowledge is still in its infancy. The newer treatment strategies of early and aggressive control of RA have gr eatly improved clinical outcomes, but improvements are still possible. Newer targeted anti-inflammatory drugs have made an important impact, yet they too are associated with numerous side effects. Short durations of moderate doses of GCs are generally well tolerated and have a positive benefit/risk ratio. Patients should be assessed for fracture risk and bone preserving agents and be prescribed calcium and vitamin D supplementation. Within a strategy of a disease modifying approach to inflammatory disease, combination therapy including a GC is effective approach.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cooper, Cyrus UNSPECIFIED UNSPECIFIED UNSPECIFIED Bardin, Thomas UNSPECIFIED orcid.org/0000-0002-5080-4790 UNSPECIFIED Brandi, Maria-Luisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Cacoub, Patrice UNSPECIFIED orcid.org/0000-0002-6727-4992 UNSPECIFIED Caminis, John UNSPECIFIED UNSPECIFIED UNSPECIFIED Civitelli, Roberto UNSPECIFIED orcid.org/0000-0003-4076-4315 UNSPECIFIED Cutolo, Maurizio UNSPECIFIED UNSPECIFIED UNSPECIFIED Dere, Willard UNSPECIFIED UNSPECIFIED UNSPECIFIED Devogelaer, Jean-Pierre UNSPECIFIED UNSPECIFIED UNSPECIFIED Diez-Perez, Adolfo UNSPECIFIED orcid.org/0000-0001-8162-0209 UNSPECIFIED Einhorn, Thomas A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Emonts, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED Ethgen, Olivier UNSPECIFIED UNSPECIFIED UNSPECIFIED Kanis, John A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaufman, Jean-Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Kvien, Tore K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lems, Willem F. UNSPECIFIED UNSPECIFIED UNSPECIFIED McCloskey, Eugene UNSPECIFIED UNSPECIFIED UNSPECIFIED Miossec, Pierre UNSPECIFIED UNSPECIFIED UNSPECIFIED Reiter, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Ringe, Johann UNSPECIFIED UNSPECIFIED UNSPECIFIED Rizzoli, Rene UNSPECIFIED UNSPECIFIED UNSPECIFIED Saag, Kenneth UNSPECIFIED UNSPECIFIED UNSPECIFIED Reginster, Jean-Yves UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-286046
DOI:	10.1007/s40520-015-0522-1
Journal or Publication Title:	Aging Clin. Exp. Res.
Volume:	28
Number:	1
Page Range:	S. 1 - 17
Date:	2016
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1720-8319
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LOW-DOSE PREDNISONE; MODIFYING ANTIRHEUMATIC DRUGS; TIGHT CONTROL STRATEGY; TO-TARGET STRATEGY; CARDIOVASCULAR EVENTS; EULAR RECOMMENDATIONS; MYOCARDIAL-INFARCTION; ORAL CORTICOSTEROIDS; DIABETES-MELLITUS; SERIOUS INFECTION Multiple languages Geriatrics & Gerontology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28604