Malter, Michael P., Bahrenberg, Christina, Niehusmann, Pitt, Elger, Christian E. and Surges, Rainer ORCID: 0000-0002-3177-8582 (2016). Features of scalp EEG in unilateral mesial temporal lobe epilepsy due to hippocampal sclerosis: Determining factors and predictive value for epilepsy surgery. Clin. Neurophysiol., 127 (2). S. 1081 - 1088. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-8952
Full text not available from this repository.Abstract
Objective: To investigate determining factors of the ictal scalp EEG pattern at seizure onset and its predictive value for postsurgical outcome in people with unilateral MTLE due to hippocampal sclerosis (MTLE-HS). Methods: Review of consecutive people with chronic MTLE-HS undergoing presurgical video-EEG telemetry. Exclusion criteria were additional epileptogenic lesions or seizure generators or compromised EEG traces at seizure-onset. Mixed linear or logistic regression models were used. Results: Inclusion of 63 patients with 219 seizures with a favorable outcome (no seizures or auras only) in 43 patients at last follow-up. Rhythmic activity at seizure-onset (RA) had a frequency of 4.7 +/- 1.5/s (range 1-8/s), mostly localized in the anterior temporal region. Postsurgical seizure outcome was not associated with any clinical or electrophysiological feature. RA in the delta-band was more often observed with shorter epilepsy duration (p = 0.002). Conclusions: RA on scalp EEG gets faster with increasing epilepsy duration, possibly via time-dependent alterations of epileptogenic networks. Neither the frequency of RA nor other EEG-features appeared to predict postsurgical seizure outcome. Significance: The results challenge the view that if patients with apparent MTLE display RA in the delta-band, seizure-onset in neocortical structures rather than in temporo-mesial tissue should be considered and further investigations should be prompted. (C) 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Item Type: | Journal Article | ||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-286181 | ||||||||||||||||||||||||
DOI: | 10.1016/j.clinph.2015.06.035 | ||||||||||||||||||||||||
Journal or Publication Title: | Clin. Neurophysiol. | ||||||||||||||||||||||||
Volume: | 127 | ||||||||||||||||||||||||
Number: | 2 | ||||||||||||||||||||||||
Page Range: | S. 1081 - 1088 | ||||||||||||||||||||||||
Date: | 2016 | ||||||||||||||||||||||||
Publisher: | ELSEVIER IRELAND LTD | ||||||||||||||||||||||||
Place of Publication: | CLARE | ||||||||||||||||||||||||
ISSN: | 1872-8952 | ||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||
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Refereed: | Yes | ||||||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/28618 |
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