Universität zu Köln

Duhan, Vikas ORCID: 0000-0002-6337-8225, Khairnar, Vishal ORCID: 0000-0002-3584-7530, Friedrich, Sarah-Kim, Zhou, Fan, Gassa, Asmae, Honke, Nadine, Shaabani, Namir, Gailus, Nicole, Botezatu, Lacramioara, Khandanpour, Cyrus ORCID: 0000-0003-4655-6269, Dittmer, Ulf, Haeussinger, Dieter, Recher, Mike ORCID: 0000-0002-9121-6936, Hardt, Cornelia, Lang, Philipp A. and Lang, Karl S. (2016). Virus-specific antibodies allow viral replication in the marginal zone, thereby promoting CD8(+)T-cell priming and viral control. Sci Rep, 6. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

Clinically used human vaccination aims to induce specific antibodies that can guarantee long-term protection against a pathogen. The reasons that other immune components often fail to induce protective immunity are still debated. Recently we found that enforced viral replication in secondary lymphoid organs is essential for immune activation. In this study we used the lymphocytic choriomeningitis virus (LCMV) to determine whether enforced virus replication occurs in the presence of virus-specific antibodies or virus-specific CD8(+)T cells. We found that after systemic recall infection with LCMV-WE the presence of virus-specific antibodies allowed intracellular replication of virus in the marginal zone of spleen. In contrast, specific antibodies limited viral replication in liver, lung, and kidney. Upon recall infection with the persistent virus strain LCMV-Docile, viral replication in spleen was essential for the priming of CD8(+)T cells and for viral control. In contrast to specific antibodies, memory CD8(+)T cells inhibited viral replication in marginal zone but failed to protect mice from persistent viral infection. We conclude that virus-specific antibodies limit viral infection in peripheral organs but still allow replication of LCMV in the marginal zone, a mechanism that allows immune boosting during recall infection and thereby guarantees control of persistent virus.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Duhan, Vikas UNSPECIFIED orcid.org/0000-0002-6337-8225 UNSPECIFIED Khairnar, Vishal UNSPECIFIED orcid.org/0000-0002-3584-7530 UNSPECIFIED Friedrich, Sarah-Kim UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhou, Fan UNSPECIFIED UNSPECIFIED UNSPECIFIED Gassa, Asmae UNSPECIFIED UNSPECIFIED UNSPECIFIED Honke, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Shaabani, Namir UNSPECIFIED UNSPECIFIED UNSPECIFIED Gailus, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED Botezatu, Lacramioara UNSPECIFIED UNSPECIFIED UNSPECIFIED Khandanpour, Cyrus UNSPECIFIED orcid.org/0000-0003-4655-6269 UNSPECIFIED Dittmer, Ulf UNSPECIFIED UNSPECIFIED UNSPECIFIED Haeussinger, Dieter UNSPECIFIED UNSPECIFIED UNSPECIFIED Recher, Mike UNSPECIFIED orcid.org/0000-0002-9121-6936 UNSPECIFIED Hardt, Cornelia UNSPECIFIED UNSPECIFIED UNSPECIFIED Lang, Philipp A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lang, Karl S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-287015
DOI:	10.1038/srep19191
Journal or Publication Title:	Sci Rep
Volume:	6
Date:	2016
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CD8 T-CELLS; IMMUNOLOGICAL MEMORY; PROTECTIVE IMMUNITY; HIV-INFECTION; HEPATITIS-C; RESPONSES; VACCINE; ACTIVATION Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28701