Al-Sawaf, Othman, Fischer, Kirsten, Eichhorst, Barbara and Hallek, Michael (2016). Targeted Therapy of CLL. Oncol. Res. Treat., 39 (12). S. 768 - 777. BASEL: KARGER. ISSN 2296-5262

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Abstract

The landscape of chronic lymphocytic leukemia (CLL) has undergone profound changes in the past years. First, the addition of CD20-targeting antibodies to conventional chemotherapy has improved the therapeutic outcome in the majority of CLL patients. Since the establishment of the critical role of the B cell receptor signaling pathway in the pathogenesis of CLL, several agents have been developed to target this pathway. Ibrutinib and idelalisib, 2 potent kinase inhibitors, have both become available for CLL therapy in the first and second line. Additionally, the observation of high expression levels of the anti-apoptotic mitochondrial protein Bcl-2 in CLL has led to the development of venetoclax, a BH3 mimetic compound that inhibits Bcl-2 and has shown high efficacy in CLL. This short review summarizes preclinical and clinical data on currently available agents in CLL and provides an outlook on upcoming new challenges in the targeted therapy of CLL. (C) 2016 S. Karger GmbH, Freiburg

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Al-Sawaf, OthmanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, KirstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eichhorst, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hallek, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-288624
DOI: 10.1159/000452786
Journal or Publication Title: Oncol. Res. Treat.
Volume: 39
Number: 12
Page Range: S. 768 - 777
Date: 2016
Publisher: KARGER
Place of Publication: BASEL
ISSN: 2296-5262
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CHRONIC LYMPHOCYTIC-LEUKEMIA; TYROSINE KINASE INHIBITOR; PREVIOUSLY UNTREATED PATIENTS; MINIMAL RESIDUAL DISEASE; B-CELL MALIGNANCIES; OPEN-LABEL; LYMPHOID MALIGNANCIES; ACALABRUTINIB ACP-196; 3-KINASE P110-DELTA; ANTI-CD20 ANTIBODYMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/28862

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