Universität zu Köln

Behringer, M., Kilian, Y., Montag, J., Geesmann, B. and Mester, J. (2016). Plasma concentration of high-mobility group box 1 (HMGB1) after 100 drop to vertical jumps and after a 1200-km bicycle race. Res. Sports Med., 24 (2). S. 119 - 130. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1543-8635

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Abstract

High-mobility group box 1 ( HMGB1) has recently been reported to be involved in proinflammation and tissue repair. Therefore, we hypothesized that HMGB1 is released into the bloodstream after eccentric exercises or prolonged endurance activities. Blood samples from 11 participants that performed 100 drop to vertical jumps ( DVJ) and from 10 participants that took part in the 1200-km 'Paris-Brest-Paris' bicycle race ( PBP) were tested for HMGB1 and creatine kinase ( CK) levels. CK increased after both DVJ ( pre: 150.6 +/- 81.5 U/L; post: 188.8 +/- 95.5 U/L 8 h: 790.5 +/- 346.4 U/L) and PBP ( pre: 81.3 +/- 36.4 U/L; post: 725.2 +/- 229.5 U/L; 12 h: 535.8 +/- 188.6 U/L), indicating membrane damage. However, HMGB1 plasma levels remained below the detection limit ( 78 pg/mL) of the applied enzyme-linked immunosorbent assay kit for all blood samples analysed. That is, neither high intensity eccentric exercises ( DVJ) nor prolonged endurance events ( PBP) seemed to affect HMGB1 levels in blood at selected time points.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Behringer, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kilian, Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Montag, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Geesmann, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mester, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-289383
DOI:	10.1080/15438627.2015.1126275
Journal or Publication Title:	Res. Sports Med.
Volume:	24
Number:	2
Page Range:	S. 119 - 130
Date:	2016
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1543-8635
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL-FREE DNA; IMMUNE-SYSTEM; IN-VIVO; EXERCISE; DANGER; DAMAGE; SIGNALS; INJURY; TRAUMA; MARKER Multiple languages Sport Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28938