Universität zu Köln

Damm-Welk, Christine, Siddiqi, Faraz, Fischer, Matthias, Hero, Barbara, Narayanan, Vignesh, Camidge, David Ross, Harris, Michael, Burke, Amos, Lehrnbecher, Thomas, Pulford, Karen, Oschlies, Ilske, Siebert, Reiner, Turner, Suzanne and Woessmann, Wilhelm (2016). Anti-ALK Antibodies in Patients with ALK-Positive Malignancies Not Expressing NPM-ALK. J. Cancer, 7 (11). S. 1383 - 1388. LAKE HAVEN: IVYSPRING INT PUBL. ISSN 1837-9664

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Abstract

Patients with Nucleophosmin (NPM)- Anaplastic Lymphoma Kinase (ALK) fusion positive Anaplastic Large Cell Lymphoma produce autoantibodies against ALK indicative of an immune response against epitopes of the chimeric fusion protein. We asked whether ALK-expression in other malignancies induces specific antibodies. Antibodies against ALK were detected in sera of one of 50 analysed ALK-expressing neuroblastoma patients, 13 of 21 ALK positive non-small cell lung carcinoma (NSCLC) patients, 13 of 22 ALK translocation-positive, but NPM-ALK-negative lymphoma patients and one of one ALK-positive rhabdomyosarcoma patient, but not in 20 healthy adults. These data suggest that boosting a pre-existent anti-ALK immune response may be more feasible for patients with ALK-positive NSCLC, lymphomas and rhabdomyosarcomas than for tumours expressing wild-type ALK.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Damm-Welk, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Siddiqi, Faraz UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Hero, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Narayanan, Vignesh UNSPECIFIED UNSPECIFIED UNSPECIFIED Camidge, David Ross UNSPECIFIED UNSPECIFIED UNSPECIFIED Harris, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Burke, Amos UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehrnbecher, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Pulford, Karen UNSPECIFIED UNSPECIFIED UNSPECIFIED Oschlies, Ilske UNSPECIFIED UNSPECIFIED UNSPECIFIED Siebert, Reiner UNSPECIFIED UNSPECIFIED UNSPECIFIED Turner, Suzanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Woessmann, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-289541
DOI:	10.7150/jca.15238
Journal or Publication Title:	J. Cancer
Volume:	7
Number:	11
Page Range:	S. 1383 - 1388
Date:	2016
Publisher:	IVYSPRING INT PUBL
Place of Publication:	LAKE HAVEN
ISSN:	1837-9664
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANAPLASTIC LYMPHOMA KINASE; LARGE-CELL LYMPHOMA; LUNG-CANCER; TYROSINE KINASE; NEUROBLASTOMA; GENE; FEATURES; DISEASE; ALCL; IDENTIFICATION Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28954