Damm-Welk, Christine, Siddiqi, Faraz, Fischer, Matthias, Hero, Barbara, Narayanan, Vignesh, Camidge, David Ross, Harris, Michael, Burke, Amos, Lehrnbecher, Thomas, Pulford, Karen, Oschlies, Ilske, Siebert, Reiner, Turner, Suzanne and Woessmann, Wilhelm (2016). Anti-ALK Antibodies in Patients with ALK-Positive Malignancies Not Expressing NPM-ALK. J. Cancer, 7 (11). S. 1383 - 1388. LAKE HAVEN: IVYSPRING INT PUBL. ISSN 1837-9664

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Abstract

Patients with Nucleophosmin (NPM)- Anaplastic Lymphoma Kinase (ALK) fusion positive Anaplastic Large Cell Lymphoma produce autoantibodies against ALK indicative of an immune response against epitopes of the chimeric fusion protein. We asked whether ALK-expression in other malignancies induces specific antibodies. Antibodies against ALK were detected in sera of one of 50 analysed ALK-expressing neuroblastoma patients, 13 of 21 ALK positive non-small cell lung carcinoma (NSCLC) patients, 13 of 22 ALK translocation-positive, but NPM-ALK-negative lymphoma patients and one of one ALK-positive rhabdomyosarcoma patient, but not in 20 healthy adults. These data suggest that boosting a pre-existent anti-ALK immune response may be more feasible for patients with ALK-positive NSCLC, lymphomas and rhabdomyosarcomas than for tumours expressing wild-type ALK.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Damm-Welk, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siddiqi, FarazUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hero, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Narayanan, VigneshUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Camidge, David RossUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harris, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burke, AmosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lehrnbecher, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pulford, KarenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oschlies, IlskeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siebert, ReinerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Turner, SuzanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Woessmann, WilhelmUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-289541
DOI: 10.7150/jca.15238
Journal or Publication Title: J. Cancer
Volume: 7
Number: 11
Page Range: S. 1383 - 1388
Date: 2016
Publisher: IVYSPRING INT PUBL
Place of Publication: LAKE HAVEN
ISSN: 1837-9664
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ANAPLASTIC LYMPHOMA KINASE; LARGE-CELL LYMPHOMA; LUNG-CANCER; TYROSINE KINASE; NEUROBLASTOMA; GENE; FEATURES; DISEASE; ALCL; IDENTIFICATIONMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/28954

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