Universität zu Köln

Horn, M., Reichart, F., Natividad-Tietz, S., Diaz, D. and Neundorf, I. (2016). Tuning the properties of a novel short cell-penetrating peptide by intramolecular cyclization with a triazole bridge. Chem. Commun., 52 (11). S. 2261 - 2265. CAMBRIDGE: ROYAL SOC CHEMISTRY. ISSN 1364-548X

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Abstract

Cell-penetrating peptides (CPPs) present a versatile alternative to viral gene delivery vectors, addressing the still challenging task to suitably transport the desired gene to the target cell. In this work, the rational design of triazole-bridged CPPs and their detailed investigation concerning peptide/lipid interactions, using also NMR-based structure calculations, are reported.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Horn, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reichart, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Natividad-Tietz, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Diaz, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Neundorf, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-291331
DOI:	10.1039/c5cc08938g
Journal or Publication Title:	Chem. Commun.
Volume:	52
Number:	11
Page Range:	S. 2261 - 2265
Date:	2016
Publisher:	ROYAL SOC CHEMISTRY
Place of Publication:	CAMBRIDGE
ISSN:	1364-548X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CANCER-CELLS; CONFORMATIONAL-ANALYSIS; BIOLOGICAL-ACTIVITY; CYCLIC-PEPTIDES; DELIVERY; DESIGN; AZIDE Multiple languages Chemistry, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/29133