Universität zu Köln

Herling, Marco, Schroeder, L., Awerkiew, Sabine, Chakupurakal, Geothy, Holtick, Udo, Kaiser, Rolf, Pfister, Herbert, Scheid, Christof and Di Cristanziano, Veronica (2016). Persistent CMV infection after allogeneic hematopoietic stem cell transplantation in a CMV-seronegative donor-to-positive recipient constellation: Development of multidrug resistance in the absence of anti-viral cellular immunity. J. Clin. Virol., 74. S. 57 - 61. AMSTERDAM: ELSEVIER. ISSN 1873-5967

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Abstract

We describe a case of persistent cytomegalovirus (CMV) infection after allogeneic hematopoietic stem cell transplantation (allo-HSCT) with discordant and high-risk (D-/R+) constellation of CMV serostatus. Despite the use of different and innovative antiviral strategies, viral replication could not be suppressed successfully promoting a protracted CMV colitis associated with severe gastrointestinal graft-versus-host disease (GI GVHD). We illustrate that the development of multidrug viral resistance, the failure to mount a CMV-specific cellular immune response, as confirmed by QuantiFERON (R)-CMV (Qiagen) assay, and the refractory GVHD requiring prolonged immunosuppression were the main factors contributing to persistent viral replication and the fulminant unfavorable course. (C) 2015 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Herling, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeder, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Awerkiew, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Chakupurakal, Geothy UNSPECIFIED UNSPECIFIED UNSPECIFIED Holtick, Udo UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaiser, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfister, Herbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheid, Christof UNSPECIFIED UNSPECIFIED UNSPECIFIED Di Cristanziano, Veronica UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-292014
DOI:	10.1016/j.jcv.2015.11.033
Journal or Publication Title:	J. Clin. Virol.
Volume:	74
Page Range:	S. 57 - 61
Date:	2016
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1873-5967
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN CYTOMEGALOVIRUS; DRUG-RESISTANCE; MUTATIONS; GANCICLOVIR; EMERGENCE; FOSCARNET; DYNAMICS; DISEASE Multiple languages Virology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/29201