Blanck, Oliver ORCID: 0000-0003-1391-1308, Wang, Lei, Baus, Wolfgang, Grimm, Jimm, Lacornerie, Thomas ORCID: 0000-0001-8994-5999, Nilsson, Joakim, Luchkovskyi, Sergii, Palazon Cano, Isabel, Shou, Zhenyu, Ayadi, Myriam, Treuer, Harald, Viard, Romain, Siebert, Frank-Andre, Chan, Mark K. H., Hildebrandt, Guido, Dunst, Juergen, Imhoff, Detlef, Wurster, Stefan, Wolff, Robert, Romanelli, Pantaleo, Lartigau, Eric, Semrau, Robert, Soltys, Scott G. and Schweikard, Achim (2016). Inverse treatment planning for spinal robotic radiosurgery: an international multi-institutional benchmark trial. J. Appl. Clin. Med. Phys, 17 (3). S. 313 - 331. HOBOKEN: WILEY. ISSN 1526-9914

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Abstract

Stereotactic radiosurgery (SRS) is the accurate, conformal delivery of high-dose radiation to well-defined targets while minimizing normal structure doses via steep dose gradients. While inverse treatment planning (ITP) with computerized optimization algorithms are routine, many aspects of the planning process remain user-dependent. We performed an international, multi-institutional benchmark trial to study planning variability and to analyze preferable ITP practice for spinal robotic radiosurgery. 10 SRS treatment plans were generated for a complex-shaped spinal metastasis with 21 Gy in 3 fractions and tight constraints for spinal cord (V-14Gy < 2 cc, V-18Gy < 0.1 cc) and target (coverage > 95%). The resulting plans were rated on a scale from 1 to 4 (excellent-poor) in five categories (constraint compliance, optimization goals, low-dose regions, ITP complexity, and clinical acceptability) by a blinded review panel. Additionally, the plans were mathematically rated based on plan indices (critical structure and target doses, conformity, monitor units, normal tissue complication probability, and treatment time) and compared to the human rankings. The treatment plans and the reviewers' rankings varied substantially among the participating centers. The average mean overall rank was 2.4 (1.2-4.0) and 8/10 plans were rated excellent in at least one category by at least one reviewer. The mathematical rankings agreed with the mean overall human rankings in 9/10 cases pointing toward the possibility for sole mathematical plan quality comparison. The final rankings revealed that a plan with a well-balanced trade-off among all planning objectives was preferred for treatment by most participants, reviewers, and the mathematical ranking system. Furthermore, this plan was generated with simple planning techniques. Our multi-institutional planning study found wide variability in ITP approaches for spinal robotic radiosurgery. The participants', reviewers', and mathematical match on preferable treatment plans and ITP techniques indicate that agreement on treatment planning and plan quality can be reached for spinal robotic radiosurgery.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Blanck, OliverUNSPECIFIEDorcid.org/0000-0003-1391-1308UNSPECIFIED
Wang, LeiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baus, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grimm, JimmUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lacornerie, ThomasUNSPECIFIEDorcid.org/0000-0001-8994-5999UNSPECIFIED
Nilsson, JoakimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luchkovskyi, SergiiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Palazon Cano, IsabelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shou, ZhenyuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ayadi, MyriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Treuer, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Viard, RomainUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siebert, Frank-AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chan, Mark K. H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hildebrandt, GuidoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dunst, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Imhoff, DetlefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wurster, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolff, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Romanelli, PantaleoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lartigau, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Semrau, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soltys, Scott G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schweikard, AchimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-292842
DOI: 10.1120/jacmp.v17i3.6151
Journal or Publication Title: J. Appl. Clin. Med. Phys
Volume: 17
Number: 3
Page Range: S. 313 - 331
Date: 2016
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1526-9914
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
STEREOTACTIC RADIOSURGERY; CONSENSUS GUIDELINES; RADIATION-THERAPY; PROSTATE-CANCER; TREATMENT PLANS; RADIOTHERAPY; OPTIMIZATION; COLLIMATOR; BRAIN; IMRTMultiple languages
Radiology, Nuclear Medicine & Medical ImagingMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/29284

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