Universität zu Köln

Randerath, Winfried J., Treml, Marcel, Priegnitz, Christina, Hedner, Jan, Sommermeyer, Dirk, Zou, Ding, Ficker, Joachim H., Fietze, Ingo, Penzel, Thomas ORCID: 0000-0002-4304-0112, Sanner, Bernd and Grote, Ludger (2016). Parameters of Overnight Pulse Wave under Treatment in Obstructive Sleep Apnea. Respiration, 92 (3). S. 136 - 144. BASEL: KARGER. ISSN 1423-0356

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Abstract

Background: Sleep-related breathing disorders may promote cardiovascular (CV) diseases. A novel and differentiated approach to overnight photoplethysmographic pulse wave analysis, which includes risk assessment and measurement of various pulse wave characteristics, has been evaluated in obstructive sleep apnea (OSA).Objectives: The purpose of this study was to assess if and which of the differentiated pulse wave characteristics might be influenced by OSA treatment with positive airway pressure (PAP).Methods: The study included two protocols. In the case-control study (group A), pulse wave-derived CV risk indices recorded during PAP therapy were compared with those obtained in age, body mass index, and CV risk class-matched patients with untreated OSA (n = 67/67). In the prospective PAP treatment study (group B), 17 unselected patients undergoing a full-night sleep test at baseline and after 23 +/- 19 weeks of treatment were analyzed. Results: In untreated OSA patients (group A), the overnight hypoxic load was increased (SpO(2) index 38.7 +/- 17.5 vs. 24.0 +/- 11.1, p < 0.001) and the pulse wave attenuation index (PWA-I) was lower (29.4 +/- 9.2 vs. 33.5 +/- 11.8, p = 0.022) than in treated patients. In group B, PAP therapy reduced the hypoxic load and increased the PWA-I significantly. The composite CV risk index was slightly but not significantly reduced. Conclusions: PAP therapy modified the hypoxic load and pulse wave-derived markers. The PWA-I - associated with sympathetic vascular tone - was most prominently modified by PAP. This novel approach to markers of CV function should be further evaluated in prospective studies. (C) 2016 S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Randerath, Winfried J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Treml, Marcel UNSPECIFIED UNSPECIFIED UNSPECIFIED Priegnitz, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Hedner, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Sommermeyer, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Zou, Ding UNSPECIFIED UNSPECIFIED UNSPECIFIED Ficker, Joachim H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fietze, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Penzel, Thomas UNSPECIFIED orcid.org/0000-0002-4304-0112 UNSPECIFIED Sanner, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Grote, Ludger UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-293375
DOI:	10.1159/000448248
Journal or Publication Title:	Respiration
Volume:	92
Number:	3
Page Range:	S. 136 - 144
Date:	2016
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1423-0356
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BLOOD-PRESSURE; CARDIOVASCULAR RISK; AIRWAY-OBSTRUCTION; HYPERTENSION; COHORT; CPAP; ASSOCIATION; AROUSAL; PREVALENCE; ALGORITHM Multiple languages Respiratory System Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/29337