Universität zu Köln

Koppara, Alexander ORCID: 0000-0002-3577-6349, Wolfsgruber, Steffen, Kleineidam, Luca, Schmidtke, Klaus, Froelich, Lutz, Kurz, Alexander, Schulz, Stefanie, Hampel, Harald, Heuser, Isabella, Peters, Oliver, Reischies, Friedel M., Jahn, Holger ORCID: 0000-0003-3607-7651, Luckhaus, Christian, Huell, Michael, Gertz, Hermann-Josef, Schroeder, Johannes, Pantel, Johannes, Rienhoff, Otto, Ruether, Eckart, Henn, Fritz, Wiltfang, Jens ORCID: 0000-0003-1492-5330, Maier, Wolfgang, Jessen, Frank, Kornhuber, Johannes ORCID: 0000-0002-8096-3987 and Wagner, Michael ORCID: 0000-0003-2589-6440 (2016). The Latent Dementia Phenotype delta is Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment. J. Alzheimers Dis., 49 (2). S. 547 - 561. AMSTERDAM: IOS PRESS. ISSN 1875-8908

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Abstract

Background: The recently proposed latent variable delta is a new tool for dementia case finding. It is built in a structural equation modeling framework of cognitive and functional data and constitutes a novel endophenotype for Alzheimer's disease (AD) research and clinical trials. Objective: To investigate the association of delta with AD biomarkers and to compare the prediction of d with established scales for conversion to dementia in patients with mild cognitive impairment (MCI). Methods: Using data from a multicenter memory clinic study, we examined the external associations of the latent variable delta and compared delta with well-established cognitive and functional scales and cognitive-functional composite scores. For that purpose, logistic regressions with cerebrospinal fluid (CSF) biomarkers and conversion to dementia as dependent variables were performed with the investigated scores. The models were tested for significant differences. Results: In patients with MCI, delta based on a broad range of cognitive scales (including the ADAS-cog, the MMSE, and the CERAD neuropsychological battery) predicted an abnormal CSF A beta(42)/tau ratio indicative of AD (n = 340, AUC = 0.78, p < 0.001), and predicted incident dementia within 1-3 years of follow-up (n = 525, AUC= 0.84, p < 0.001). These associations were generally stronger than for any other scale or cognitive-functional composite examined. Homologs of d based on reduced test batteries yielded somewhat lower effects. Conclusion: These findings support the interpretation of d as a construct capturing the disease-related essence of cognitive and functional impairments in patients with MCI and dementia, and suggest that d might become an analytical tool for dementia research.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koppara, Alexander UNSPECIFIED orcid.org/0000-0002-3577-6349 UNSPECIFIED Wolfsgruber, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Kleineidam, Luca UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidtke, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Froelich, Lutz UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurz, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulz, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Hampel, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Heuser, Isabella UNSPECIFIED UNSPECIFIED UNSPECIFIED Peters, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Reischies, Friedel M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jahn, Holger UNSPECIFIED orcid.org/0000-0003-3607-7651 UNSPECIFIED Luckhaus, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Huell, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Gertz, Hermann-Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeder, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Pantel, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Rienhoff, Otto UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruether, Eckart UNSPECIFIED UNSPECIFIED UNSPECIFIED Henn, Fritz UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiltfang, Jens UNSPECIFIED orcid.org/0000-0003-1492-5330 UNSPECIFIED Maier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Kornhuber, Johannes UNSPECIFIED orcid.org/0000-0002-8096-3987 UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-293560
DOI:	10.3233/JAD-150257
Journal or Publication Title:	J. Alzheimers Dis.
Volume:	49
Number:	2
Page Range:	S. 547 - 561
Date:	2016
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1875-8908
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEUROPSYCHOLOGICAL ASSESSMENT; DIFFERENTIAL-DIAGNOSIS; TOTAL SCORE; ADAS-COG; VALIDATION; CERAD; SCALE; VALIDITY; CONSENSUS; CRITERIA Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/29356