Roehr, Susanne ORCID: 0000-0001-9385-0669, Pabst, Alexander, Riedel-Heller, Steffi G., Jessen, Frank, Turana, Yuda, Handajani, Yvonne S., Brayne, Carol, Matthews, Fiona E., Stephan, Blossom C. M., Lipton, Richard B., Katz, Mindy J., Wang, Cuiling, Guerchet, Maelenn, Preux, Pierre-Marie, Mbelesso, Pascal, Ritchie, Karen, Ancelin, Marie-Laure ORCID: 0000-0002-1149-4320, Carriere, Isabelle, Guaita, Antonio, Davin, Annalisa, Vaccaro, Roberta, Kim, Ki Woong, Han, Ji Won, Suh, Seung Wan, Shahar, Suzana, Din, Normah C., Vanoh, Divya, van Boxtel, Martin, Koehler, Sebastian, Ganguli, Mary, Jacobsen, Erin P., Snitz, Beth E., Anstey, Kaarin J., Cherbuin, Nicolas ORCID: 0000-0001-6481-0748, Kumagai, Shuzo, Chen, Sanmei ORCID: 0000-0003-0811-1701, Narazaki, Kenji, Ng, Tze Pin, Gao, Qi, Gwee, Xinyi, Brodaty, Henry, Kochan, Nicole A., Trollor, Julian, Lobo, Antonio, Lopez-Anton, Raul, Santabarbara, Javier, Crawford, John D., Lipnicki, Darren M. and Sachdev, Perminder S. (2020). Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study. Alzheimers Res. Ther., 12 (1). LONDON: BMC. ISSN 1758-9193

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Abstract

Background Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer's disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts. Methods We combined individual participant data for 16 cohorts from 15 countries (members of the COSMIC consortium) and used qualitative and quantitative (Item Response Theory/IRT) harmonization techniques to estimate SCD prevalence. Results The sample comprised 39,387 cognitively unimpaired individuals above age 60. The prevalence of SCD across studies was around one quarter with both qualitative harmonization/QH (23.8%, 95%CI = 23.3-24.4%) and IRT (25.6%, 95%CI = 25.1-26.1%); however, prevalence estimates varied largely between studies (QH 6.1%, 95%CI = 5.1-7.0%, to 52.7%, 95%CI = 47.4-58.0%; IRT: 7.8%, 95%CI = 6.8-8.9%, to 52.7%, 95%CI = 47.4-58.0%). Across studies, SCD prevalence was higher in men than women, in lower levels of education, in Asian and Black African people compared to White people, in lower- and middle-income countries compared to high-income countries, and in studies conducted in later decades. Conclusions SCD is frequent in old age. Having a quarter of older individuals with SCD warrants further investigation of its significance, as a risk stage for AD and other dementias, and of ways to help individuals with SCD who seek medical advice. Moreover, a standardized instrument to measure SCD is needed to overcome the measurement variability currently dominant in the field.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Roehr, SusanneUNSPECIFIEDorcid.org/0000-0001-9385-0669UNSPECIFIED
Pabst, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riedel-Heller, Steffi G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Turana, YudaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Handajani, Yvonne S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brayne, CarolUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matthews, Fiona E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stephan, Blossom C. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lipton, Richard B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katz, Mindy J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, CuilingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guerchet, MaelennUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Preux, Pierre-MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mbelesso, PascalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ritchie, KarenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ancelin, Marie-LaureUNSPECIFIEDorcid.org/0000-0002-1149-4320UNSPECIFIED
Carriere, IsabelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guaita, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Davin, AnnalisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vaccaro, RobertaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kim, Ki WoongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Han, Ji WonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Suh, Seung WanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shahar, SuzanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Din, Normah C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vanoh, DivyaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Boxtel, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koehler, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ganguli, MaryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jacobsen, Erin P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Snitz, Beth E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anstey, Kaarin J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cherbuin, NicolasUNSPECIFIEDorcid.org/0000-0001-6481-0748UNSPECIFIED
Kumagai, ShuzoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen, SanmeiUNSPECIFIEDorcid.org/0000-0003-0811-1701UNSPECIFIED
Narazaki, KenjiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ng, Tze PinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gao, QiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gwee, XinyiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brodaty, HenryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kochan, Nicole A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trollor, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lobo, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopez-Anton, RaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Santabarbara, JavierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crawford, John D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lipnicki, Darren M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sachdev, Perminder S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-307746
DOI: 10.1186/s13195-020-00734-y
Journal or Publication Title: Alzheimers Res. Ther.
Volume: 12
Number: 1
Date: 2020
Publisher: BMC
Place of Publication: LONDON
ISSN: 1758-9193
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MINI-MENTAL-STATE; MEMORY COMPLAINTS; DEMENTIA; DETERIORATION; PERFORMANCE; COMMUNITY; FRAMEWORK; CRITERIA; PEOPLE; HEALTHMultiple languages
Clinical Neurology; NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/30774

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