Universität zu Köln

Klein, Sebastian ORCID: 0000-0002-2188-9377, Gildenblat, Jacob, Ihle, Michaele Angelika, Merkelbach-Bruse, Sabine, Noh, Ka-Won, Peifer, Martin, Quaas, Alexander and Buettner, Reinhard (2020). Deep learning for sensitive detection of Helicobacter Pylori in gastric biopsies. BMC Gastroenterol., 20 (1). LONDON: BMC. ISSN 1471-230X

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Abstract

BackgroundHelicobacter pylori, a 2x1 mu m spiral-shaped bacterium, is the most common risk factor for gastric cancer worldwide. Clinically, patients presenting with symptoms of gastritis, routinely undergo gastric biopsies. The following histo-morphological evaluation dictates therapeutic decisions, where antibiotics are used for H. pylori eradication. There is a strong rational to accelerate the detection process of H. pylori on histological specimens, using novel technologies, such as deep learning. MethodsWe designed a deep-learning-based decision support algorithm that can be applied on regular whole slide images of gastric biopsies. In detail, we can detect H. pylori both on Giemsa- and regular H&E stained whole slide images.ResultsWith the help of our decision support algorithm, we show an increased sensitivity in a subset of 87 cases that underwent additional PCR- and immunohistochemical testing to define a sensitive ground truth of HP presence. For Giemsa stained sections, the decision support algorithm achieved a sensitivity of 100% compared to 68.4% (microscopic diagnosis), with a tolerable specificity of 66.2% for the decision support algorithm compared to 92.6 (microscopic diagnosis).ConclusionTogether, we provide the first evidence of a decision support algorithm proving as a sensitive screening option for H. pylori that can potentially aid pathologists to accurately diagnose H. pylori presence on gastric biopsies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Klein, Sebastian UNSPECIFIED orcid.org/0000-0002-2188-9377 UNSPECIFIED Gildenblat, Jacob UNSPECIFIED UNSPECIFIED UNSPECIFIED Ihle, Michaele Angelika UNSPECIFIED UNSPECIFIED UNSPECIFIED Merkelbach-Bruse, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Noh, Ka-Won UNSPECIFIED UNSPECIFIED UNSPECIFIED Peifer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Quaas, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-308237
DOI:	10.1186/s12876-020-01494-7
Journal or Publication Title:	BMC Gastroenterol.
Volume:	20
Number:	1
Date:	2020
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1471-230X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INFECTION; RISK; POPULATION; MANAGEMENT; DIAGNOSIS; CANCER Multiple languages Gastroenterology & Hepatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/30823