Universität zu Köln

Shalaby, Raed, Flores-Romero, Hector ORCID: 0000-0003-0996-5717 and Garcia-Saez, Ana J. (2020). The Mysteries around the BCL-2 Family Member BOK. Biomolecules, 10 (12). BASEL: MDPI. ISSN 2218-273X

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Abstract

BOK is an evolutionarily conserved BCL-2 family member that resembles the apoptotic effectors BAK and BAX in sequence and structure. Based on these similarities, BOK has traditionally been classified as a BAX-like pro-apoptotic protein. However, the mechanism of action and cellular functions of BOK remains controversial. While some studies propose that BOK could replace BAK and BAX to elicit apoptosis, others attribute to this protein an indirect way of apoptosis regulation. Adding to the debate, BOK has been associated with a plethora of non-apoptotic functions that makes this protein unpredictable when dictating cell fate. Here, we compile the current knowledge and open questions about this paradoxical protein with a special focus on its structural features as the key aspect to understand BOK biological functions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Shalaby, Raed UNSPECIFIED UNSPECIFIED UNSPECIFIED Flores-Romero, Hector UNSPECIFIED orcid.org/0000-0003-0996-5717 UNSPECIFIED Garcia-Saez, Ana J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-309325
DOI:	10.3390/biom10121638
Journal or Publication Title:	Biomolecules
Volume:	10
Number:	12
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2218-273X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL-DEATH; BAX; APOPTOSIS; PROTEINS; BCL-X(L); EXPRESSION; DOMAIN; OLIGOMERIZATION; TRANSLOCATION; MITOCHONDRIA Multiple languages Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/30932