Universität zu Köln

Sitnilska, Vasilena, Kersten, Eveline, Altay, Lebriz, Schick, Tina, Enders, Philip ORCID: 0000-0002-9527-4957, de Jong, Eiko K., Langmann, Thomas, Hoyng, Carel B., den Hollander, Anneke, I and Fauser, Sascha (2020). Major Predictive Factors for Progression of Early to Late Age-Related Macular Degeneration. Ophthalmologica, 243 (6). S. 444 - 453. BASEL: KARGER. ISSN 1423-0267

Full text not available from this repository.

Abstract

Introduction: We present a prediction model for progression from early/intermediate to advanced age-related macular degeneration (AMD) within 5.9 years. Objectives: To evaluate the combined role of genetic, nongenetic, and phenotypic risk factors for conversion from early to late AMD over >= 5 years. Methods: Baseline phenotypic characteristics were evaluated based on color fundus photography, spectral-domain optical coherence tomography, and infrared images. Genotyping for 36 single-nucleotide polymorphisms as well as systemic lipid and complement measurements were performed. Multivariable backward logistic regression resulted in a final prediction model. Results and Conclusions: During a mean of 5.9 years of follow-up, 22.4% (n = 52) of the patients (n = 232) showed progression to late AMD. The multivariable prediction model included age, CFH variant rs1061170, pigment abnormalities, drusenoid pigment epithelial detachment (DPED), and hyperreflective foci (HRF). The model showed an area under the curve of 0.969 (95% confidence interval 0.948-0.990) and adequate calibration (Hosmer-Lemeshow test, p = 0.797). In addition to advanced age and carrying a CFH variant, pigment abnormalities, DPED, and HRF are relevant imaging biomarkers for conversion to late AMD. In clinical routine, an intensified monitoring of patients with a high-risk phenotypic profile may be suitable for the early detection of conversion to late AMD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sitnilska, Vasilena UNSPECIFIED UNSPECIFIED UNSPECIFIED Kersten, Eveline UNSPECIFIED UNSPECIFIED UNSPECIFIED Altay, Lebriz UNSPECIFIED UNSPECIFIED UNSPECIFIED Schick, Tina UNSPECIFIED UNSPECIFIED UNSPECIFIED Enders, Philip UNSPECIFIED orcid.org/0000-0002-9527-4957 UNSPECIFIED de Jong, Eiko K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Langmann, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoyng, Carel B. UNSPECIFIED UNSPECIFIED UNSPECIFIED den Hollander, Anneke, I UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-309971
DOI:	10.1159/000507196
Journal or Publication Title:	Ophthalmologica
Volume:	243
Number:	6
Page Range:	S. 444 - 453
Date:	2020
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1423-0267
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OPTICAL COHERENCE TOMOGRAPHY; COMPLEMENT ACTIVATION LEVELS; RETICULAR PSEUDODRUSEN; CHOROIDAL NEOVASCULARIZATION; DRUSEN VOLUME; RISK-FACTORS; FOLLOW-UP; FELLOW EYE; INTERMEDIATE; ASSOCIATION Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/30997