Universität zu Köln

Flores-Romero, Hector ORCID: 0000-0003-0996-5717, Ros, Uris and Garcia-Saez, Ana J. (2020). Pore formation in regulated cell death. Embo J., 39 (23). HOBOKEN: WILEY. ISSN 1460-2075

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Abstract

The discovery of alternative signaling pathways that regulate cell death has revealed multiple strategies for promoting cell death with diverse consequences at the tissue and organism level. Despite the divergence in the molecular components involved, membrane permeabilization is a common theme in the execution of regulated cell death. In apoptosis, the permeabilization of the outer mitochondrial membrane by BAX and BAK releases apoptotic factors that initiate the caspase cascade and is considered the point of no return in cell death commitment. Pyroptosis and necroptosis also require the perforation of the plasma membrane at the execution step, which involves Gasdermins in pyroptosis, and MLKL in the case of necroptosis. Although BAX/BAK, Gasdermins and MLKL share certain molecular features like oligomerization, they form pores in different cellular membranes via distinct mechanisms. Here, we compare and contrast how BAX/BAK, Gasdermins, and MLKL alter membrane permeability from a structural and biophysical perspective and discuss the general principles of membrane permeabilization in the execution of regulated cell death.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Flores-Romero, Hector UNSPECIFIED orcid.org/0000-0003-0996-5717 UNSPECIFIED Ros, Uris UNSPECIFIED UNSPECIFIED UNSPECIFIED Garcia-Saez, Ana J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-310120
DOI:	10.15252/embj.2020105753
Journal or Publication Title:	Embo J.
Volume:	39
Number:	23
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1460-2075
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BAX-DERIVED PEPTIDE; DOMAIN-LIKE PROTEIN; GASDERMIN-D PORE; FORMING PROTEINS; PROAPOPTOTIC BAX; LIPID-BILAYERS; MEMBRANE PORES; CYTOCHROME-C; ANTIMICROBIAL PEPTIDE; MEDIATES NECROPTOSIS Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31012