Schumacher-Kuckelkorn, Roswitha, Atra, Ayad, Belli, Maria Luisa, den Engelsman, Gerda, Freneaux, Paul, Gauthier, Arnaud, Heijlaerts-Klever, Anja, Scuderi, Francesca, Senent Peris, Leonor, Tewari, Sanjay, Zapletal, Ondrej, Ernst, Angela and Berthold, Frank . The reliability of bone marrow cytology as response criterion in metastatic neuroblastoma. Pediatr. Blood Cancer. HOBOKEN: WILEY. ISSN 1545-5017

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Abstract

Background The quantitative assessment of neuroblastoma cell content in bone marrow aspirates for response evaluation has been introduced recently. Data on the concordance of interobserver reports are lacking so far. Methods Investigators of seven European countries representing national reference or large oncological centers convened in 2016. They agreed to quantitatively assess routine bone marrow smears of the participating institutions and to discuss the discrepant results in joint meetings. Results From 2017 through 2019, three cytology rounds with 24, 28, and 28 bone marrow samples were run evaluating the representativity of the smears (yes/[restricted]/no) and the presence of tumor cells (yes/no and %). The comparison of the reports using kappa (Fleiss) and alpha (Krippendorff) statistics demonstrated no robust reliabilities. The agreement on the representativity was moderate to poor, on the presence of tumor cells moderate to good, and on the percentage of tumor cells slight to moderate. Though the value of cytology is unquestioned to detect even tiny metastatic cells in bone marrow, the investigators unanimously agreed that a reliable quantification of the tumor cell content in bone marrow smears is unrealistic. For the key issue of representativity, a new practical definition was developed. Conclusion For any work with bone marrow aspirates, the representativity of the material is of paramount importance. A practical definition is proposed. A reliable quantitative cytological assessment of tumor cell content in bone marrow aspirates is not feasible in metastatic neuroblastoma. Therefore, its use as response criterion should be reconsidered.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schumacher-Kuckelkorn, RoswithaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Atra, AyadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Belli, Maria LuisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
den Engelsman, GerdaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Freneaux, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gauthier, ArnaudUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heijlaerts-Klever, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scuderi, FrancescaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Senent Peris, LeonorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tewari, SanjayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zapletal, OndrejUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ernst, AngelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berthold, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-310701
DOI: 10.1002/pbc.28819
Journal or Publication Title: Pediatr. Blood Cancer
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1545-5017
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
STANDARDIZATION; CELLS; RECOMMENDATIONS; CONSENSUS; ASPIRATE; BLOODMultiple languages
Oncology; Hematology; PediatricsMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31070

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