Petry-Schmelzer, Jan Niklas ORCID: 0000-0003-0749-3840, Jergas, Hannah, Thies, Tabea, Steffen, Julia K., Reker, Paul, Dafsari, Haidar S., Muecke, Doris, Fink, Gereon R., Visser-Vandewalle, Veerle, Dembek, Till A. and Barbe, Michael T. . Network Fingerprint of Stimulation-Induced Speech Impairment in Essential Tremor. Ann. Neurol.. HOBOKEN: WILEY. ISSN 1531-8249

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Abstract

Objective This study was undertaken to gain insights into structural networks associated with stimulation-induced dysarthria (SID) and to predict stimulation-induced worsening of intelligibility in essential tremor patients with bilateral thalamic deep brain stimulation (DBS). Methods Monopolar reviews were conducted in 14 essential tremor patients. Testing included determination of SID thresholds, intelligibility ratings, and a fast syllable repetition task. Volumes of tissue activated (VTAs) were calculated to identify discriminative fibers for stimulation-induced worsening of intelligibility in a structural connectome. The resulting fiber-based atlas structure was then validated in a leave-one-out design. Results Fibers determined as discriminative for stimulation-induced worsening of intelligibility were mainly connected to the ipsilateral precentral gyrus as well as to both cerebellar hemispheres and the ipsilateral brain stem. In the thalamic area, they ran laterally to the thalamus and posteromedially to the subthalamic nucleus, in close proximity, mainly anterolaterally, to fibers beneficial for tremor control as published by Al-Fatly et al in 2019. The overlap of the respective clinical stimulation setting's VTAs with these fibers explained 62.4% (p < 0.001) of the variance of stimulation-induced change in intelligibility in a leave-one-out analysis. Interpretation This study demonstrates that SID in essential tremor patients is associated with both motor cortex and cerebellar connectivity. Furthermore, the identified fiber-based atlas structure might contribute to future postoperative programming strategies to achieve optimal tremor control without speech impairment in essential tremor patients with thalamic DBS. ANN NEUROL 2020

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Petry-Schmelzer, Jan NiklasUNSPECIFIEDorcid.org/0000-0003-0749-3840UNSPECIFIED
Jergas, HannahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thies, TabeaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steffen, Julia K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reker, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dafsari, Haidar S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muecke, DorisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, Gereon R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Visser-Vandewalle, VeerleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dembek, Till A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barbe, Michael T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-310741
DOI: 10.1002/ana.25958
Journal or Publication Title: Ann. Neurol.
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1531-8249
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DEEP BRAIN-STIMULATION; NEUROSTIMULATION; INTELLIGIBILITY; RECONSTRUCTION; ACTIVATION; LOCATION; OUTCOMESMultiple languages
Clinical Neurology; NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31074

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