Universität zu Köln

Petry-Schmelzer, Jan Niklas ORCID: 0000-0003-0749-3840, Jergas, Hannah, Thies, Tabea, Steffen, Julia K., Reker, Paul, Dafsari, Haidar S., Mücke, Doris ORCID: 0000-0002-6217-3121, Fink, Gereon R., Visser-Vandewalle, Veerle, Dembek, Till A. and Barbe, Michael T. (2020). Network Fingerprint of Stimulation-Induced Speech Impairment in Essential Tremor. Ann. Neurol.. HOBOKEN: WILEY. ISSN 1531-8249

Full text not available from this repository.

Abstract

Objective This study was undertaken to gain insights into structural networks associated with stimulation-induced dysarthria (SID) and to predict stimulation-induced worsening of intelligibility in essential tremor patients with bilateral thalamic deep brain stimulation (DBS). Methods Monopolar reviews were conducted in 14 essential tremor patients. Testing included determination of SID thresholds, intelligibility ratings, and a fast syllable repetition task. Volumes of tissue activated (VTAs) were calculated to identify discriminative fibers for stimulation-induced worsening of intelligibility in a structural connectome. The resulting fiber-based atlas structure was then validated in a leave-one-out design. Results Fibers determined as discriminative for stimulation-induced worsening of intelligibility were mainly connected to the ipsilateral precentral gyrus as well as to both cerebellar hemispheres and the ipsilateral brain stem. In the thalamic area, they ran laterally to the thalamus and posteromedially to the subthalamic nucleus, in close proximity, mainly anterolaterally, to fibers beneficial for tremor control as published by Al-Fatly et al in 2019. The overlap of the respective clinical stimulation setting's VTAs with these fibers explained 62.4% (p < 0.001) of the variance of stimulation-induced change in intelligibility in a leave-one-out analysis. Interpretation This study demonstrates that SID in essential tremor patients is associated with both motor cortex and cerebellar connectivity. Furthermore, the identified fiber-based atlas structure might contribute to future postoperative programming strategies to achieve optimal tremor control without speech impairment in essential tremor patients with thalamic DBS. ANN NEUROL 2020

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Petry-Schmelzer, Jan Niklas UNSPECIFIED orcid.org/0000-0003-0749-3840 UNSPECIFIED Jergas, Hannah UNSPECIFIED UNSPECIFIED UNSPECIFIED Thies, Tabea UNSPECIFIED UNSPECIFIED UNSPECIFIED Steffen, Julia K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reker, Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED Dafsari, Haidar S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mücke, Doris UNSPECIFIED orcid.org/0000-0002-6217-3121 UNSPECIFIED Fink, Gereon R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Dembek, Till A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbe, Michael T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-310741
DOI:	10.1002/ana.25958
Journal or Publication Title:	Ann. Neurol.
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1531-8249
Language:	English
Faculty:	Faculty of Arts and Humanities
Divisions:	Faculty of Arts and Humanities > Fächergruppe 1: Kunstgeschichte, Musikwissenschaft, Medienkultur und Theater, Linguistik, IDH > Institut für Linguistik > Phonetik
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP BRAIN-STIMULATION; NEUROSTIMULATION; INTELLIGIBILITY; RECONSTRUCTION; ACTIVATION; LOCATION; OUTCOMES Multiple languages Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/31074